Ariane Bruder‐Nascimento

This study shows that activating Beclin1 prevents aldosterone-induced cardiovascular damage by restoring autophagy, protecting vascular and cardiac function.

This study shows that Ang II enhances CCL5/CCR5 signaling, leading to mitochondrial dysfunction and oxidative stress in vascular smooth muscle cells, contributing to vascular injury in hypertension.

This study identifies CASC15 as a regulator of vascular smooth muscle cell growth fate and vascular remodeling, showing it controls proliferation versus hypertrophy through mitotic fidelity.

This study shows that progranulin deficiency worsens age-related vascular damage in mice, affecting endothelial function and vascular remodeling.

This study shows that progranulin (PGRN) is essential for vascular contractility by regulating mitochondrial function, mitophagy, and redox signaling in vascular smooth muscle cells.

This study shows that CCL5/CCR5 contributes to aldosterone-induced hypertension, vascular injury, and renal damage by promoting inflammation and oxidative stress.