Menglan Li

This study develops SynNotch reporters to visualize force transmission and downstream signaling in immunoreceptors in vivo, showing force acts as a co-stimulus for CD40 and TCR signaling.

This study evaluates how CD8/CD4 coreceptors affect T cell function by analyzing TCR-pMHC catch and slip bonds, finding that coreceptors enhance bond metrics and TCR sensitivity and specificity.

This study shows mechanical force is critical for PD-1 function, as soluble PD-L1 lacks the mechanical support needed to trigger PD-1 signaling.