Moira Pasquier

This study shows that DNMT1 loss causes hypomethylation in late replicating domains but also leads to hypermethylation in some domains due to DNMT3A activity, altering chromatin states.

This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.