Alia M. Obeidat

The paper uses single-nucleus multiome sequencing to analyze subchondral bone in OA, finding increased osteocyte SMAD2/3 activity and chondrocyte-derived FN1 signaling with disease severity.

This study shows that repeated NGF injections into mouse knees cause multiple OA-like features without cartilage damage.

This study shows that acute systemic macrophage depletion reduces pain-related behaviors in osteoarthritic mice without affecting joint damage.

This paper develops a 3D imaging workflow using clearing-enabled light sheet microscopy to map mouse knee joint innervation and demonstrates changes in nerve density after NGF injection.

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.