Karl L. Ocius

This study shows lipid conjugates have different effects on cytosolic accumulation in E. coli and mammalian cells, highlighting context-dependent permeation strategies.

This study identifies LdtB as essential for Mycobacterium tuberculosis acid resistance by linking peptidoglycan cross-linking to intrabacterial pH homeostasis and antibiotic susceptibility.

This paper develops a high-throughput peptide-based assay to profile L,D-transpeptidase activity and inhibitors in mycobacteria, showing potent inhibition by (carba)penems.

The paper identifies benzimidazole compounds, including nocodazole, as NOD2 agonists with potential therapeutic benefits over existing MDP-based agonists.

The paper shows that chemical modifications of MHC-I epitopes affect T cell recognition, demonstrating that antigenic identity depends on both sequence and chemical history.

The paper evaluates how structural modifications like macrocyclization and N-alkylation affect peptide accumulation in Mycobacterium tuberculosis using a novel assay, showing macrocyclization generally enhances accumulation while N-alkylation has context-dependent effects.

This study identifies a new family of LDTs in C. difficile that catalyze 3-3 peptidoglycan crosslinking, essential for viability and distinct from previously known YkuD domain LDTs.

This study isolates and analyzes peptidoglycan from fecal samples of mice and humans to explore its role in host-microbiome interactions and health.