Sabine Ehrt

This study shows that interstitial macrophages prevent tuberculosis relapse by restricting Mtb immune evasion during latent infection.

This study identifies Mtb's LCFA resistome and shows TB15.3 as a critical metabolic regulator preventing LCFA toxicity during infection.

The paper identifies an unusual [3Fe-4S] cluster in EtfD from Mycobacterium smegmatis and shows its role in linking β-oxidation to proton pumping in the electron transport chain.

This study identifies LdtB as essential for Mycobacterium tuberculosis acid resistance by linking peptidoglycan cross-linking to intrabacterial pH homeostasis and antibiotic susceptibility.

The paper identifies Rv2571c as a mycobacterial ion channel that mediates pyrazinamide resistance by regulating cytoplasmic acidification.

This study shows that Rv3400, a β-phosphoglucomutase in M. tuberculosis, is essential for trehalose metabolism, as its deletion increases β-D-glucose 1-phosphate and causes growth defects on trehalose.

This study identifies a periplasmic protein complex in Mtb that supports arabinofuranosyltransferase activity and contributes to intrinsic drug resistance.

This paper introduces PCL analysis to predict small molecule mechanisms of action in Mycobacterium tuberculosis using PROSPECT data, achieving high sensitivity and precision in MOA prediction.

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

This study develops a 'suicide' BCG strain that is safely eliminated in immunocompromised hosts but induces stronger immune responses and better protection against Mtb in macaques.

This study identifies host-pathogen genetic interactions influencing tuberculosis susceptibility using a genetically diverse mouse panel and Mtb mutants.

This paper introduces a statistical method using Zero-Inflated Negative Binomial regression to identify genes with significant variability in insertion counts across multiple conditions in TnSeq data.