Mahendra D. Chordia

The paper identifies benzimidazole compounds, including nocodazole, as NOD2 agonists with potential therapeutic benefits over existing MDP-based agonists.

This paper introduces D-CLAP, a split-luciferin assay to measure real-time cytosolic accumulation of compounds in live mycobacteria, showing that modifying carboxylates increases accumulation and antimycobacterial activity.

The paper identifies Hsp90 inhibitors as MHC-I inducers and develops novel compounds using click chemistry to enhance T cell activation and reduce toxicity.

The paper evaluates how structural modifications like macrocyclization and N-alkylation affect peptide accumulation in Mycobacterium tuberculosis using a novel assay, showing macrocyclization generally enhances accumulation while N-alkylation has context-dependent effects.

This paper shows that the mycomembrane of Mycobacterium tuberculosis and M. smegmatis differentially and heterogeneously restricts antibiotic permeation using the PAC-MAN method.

The paper introduces the CHAMP assay to measure cytosolic drug accumulation in mammalian cells, showing how molecular structure affects penetration.

This paper introduces a luciferase-based assay to measure antibiotic permeability into the cytosol of Gram-negative bacteria and demonstrates its ability to track intracellular accumulation in real time.