Yamami Nakamura

This study shows that thymic imprinting causes naive CD4 T cells to have different cytokine responses, leading to varied Treg induction and effector function.

This study shows that oral antigen exposure with co-stimulation blockade generates stable regulatory T cells in antigen-sensitized mice, establishing long-term immune tolerance.

This study shows that Ikzf1 associates with Foxp3 to repress genes in Treg cells, and disrupting this association leads to autoimmunity and enhanced tumor immunity.