Daisuke Motooka

This study uses purification-free cryo-EM to analyze endogenous macromolecular assemblies from tardigrade samples, revealing structures like vitellogenin and ferritin.

This study uses real-time near-infrared imaging to distinguish nasopharyngeal colonization from aspiration of Streptococcus pneumoniae and shows aspiration triggers severe disease.

The paper develops a core genome MLST scheme for Bartonella henselae, revealing higher genetic resolution and associations between bafA subtypes and phenotypic differences in endothelial cell interactions.

The paper shows that infant acquisition of Stickland-metabolizing bacteria prevents Clostridium botulinum infection by competing for amino acids.

This study shows retinoid signaling specifies frontonasal identity and represses maxillary identity in cranial neural crest cells during facial development in mice.

The paper identifies issues with the p16-3MR mouse model for in vivo bioluminescence imaging, showing that fur shaving is necessary for accurate signal detection and that previous results may be unreliable.

This study shows that reducing gut ceramidase Asah2 activity slows ageing in vertebrates by altering ceramide levels and microbiota composition.

This study identifies nutrient acquisition genes critical for Edwardsiella tarda survival in NSTI using TraDIS, showing metabolic adaptation drives pathogenesis.

This study uses human respiratory organoids to show that a cattle-derived H5N1 isolate replicates efficiently but suppresses innate immune responses, explaining its mild clinical presentation in humans.

The paper identifies genetic variations in emm89 Streptococcus pyogenes associated with invasive infections using genome-wide association studies and validates one mutation's effect on bacterial growth.

This study shows that oral antigen exposure with co-stimulation blockade generates stable regulatory T cells in antigen-sensitized mice, establishing long-term immune tolerance.

This study uses spatial transcriptomics to identify medullary niche features in thymoma and thymic hyperplasia associated with myasthenia gravis pathogenesis.

This study shows that age-related structural changes in the zona pellucida reduce fertilization rates in mice by impairing cumulus-oocyte interactions and sperm binding.

This study identifies the Keap1-Nrf2 pathway as a regulator of TGF-β-mediated CTGF expression in fibroblasts, showing that Nrf2 with Ddx54 suppresses profibrotic genes and reduces fibrosis in mouse heart and kidney.

The paper shows that the cell wall polymer, not active polymerization, is critical for membrane partitioning in Mycobacterium smegmatis.

The paper introduces iSCseq, a method that captures subcellular transcriptomic changes in living cells, revealing new osteoclast subsets and subcellular connections.