A list by @biology · 1 papers · 0 followers
Saša Jereb, Lia R. D’Alessandro, Nader Morshed…·Benjamin E. Deverman
The paper compares microglia-targeted AAVs, finding that capsid choice affects in vitro efficiency but not in vivo transduction when using specific promoters.
Papers closest to the centre of this list, not already in it.
Miguel C. Santoscoy, Paula Espinoza, Killian S. Hanlon…·Casey A. Maguire
The paper identifies an AAV capsid, MC5, that efficiently and specifically transduces microglia via direct and intracerebroventricular injection in mice.
Ryo Aoki, Ayumu Konno, Nobutake Hosoi…·Hirokazu Hirai
This paper develops an AAV vector system with optimized miR.Ts placement to achieve specific and efficient transgene expression in microglia.
Nengsong Luo, Kunzhang Lin, Yuxiang Cai…·Fuqiang Xu
This paper evaluates AAV11 vectors with IBA1 promoter and miRNA-9 sequences for microglia-specific transduction, finding AAV11 provides high specificity and efficiency in transducing microglia across brain regions and spinal cord.
Carolina Serrano, Sergio Giuseppe Cananzi, Tianjin Shen…·Chun‐Li Zhang
This paper identifies a short human IBA1 promoter that enables specific targeting of microglia using AAV vectors, achieving up to 95% microglia transduction.
Margaret E. Maes, Gabriele M Wögenstein, Gloria Colombo…·Sandra Siegert
The paper optimizes AAV2/6 for microglial targeting in the retina, showing enhanced transduction during photoreceptor degeneration through capsid modification and Cre-dependent cassette validation.
N. C. Flytzanis, N. Goeden, D. Goertsen…·V. Gradinaru
The paper identifies AAV capsid variants that target the brain with high specificity and avoid liver expression in mice and marmoset non-human primates.
Ajay Extross, Ezequiel Marrón Fernández de Velasco, Yungui He…·Daniel Schmidt
This paper develops AAV-m5, a nanobody-functionalized AAV vector that targets neurons via mGluR5, achieving efficient and specific transduction in the CNS without relying on promoters.