Author

D. Goertsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

V. Gradinaru· 3 shared T. F. Shay· 2 shared X. Chen· 2 shared X. Ding· 2 shared A. Akrami· 1 shared A. Cummins· 1 shared A. Keller· 1 shared A. S. Fox· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioengineering

V. Gradinaru

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Author profile →

3 papers

Recent·Most cited

Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier

T. F. Shay, E. E. Sullivan, X. Ding, X. Chen, S. R. Kumar, D. Goertsen, D. Brown, J. Vielmetter, M. Borsos, A. W. Lam, V. Gradinaru

The paper identifies two new receptors, Ly6c1 and Car4/CA4, for crossing the blood-brain barrier using AAV vectors and computational modeling.

bioRxiv · Jan 12, 2023Bioengineering

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

X. Chen, D. A. Wolfe, D. Sivadasan Bindu, M. Zhang, N. Taskin, D. Goertsen, T. F. Shay, E. Sullivan, S. Ravindra Kumar, S.-F. Huang, C. M. Arokiaraj, V. Plattner, L. J. Campos, J. K. Mich, D. Monet, , V. Gradinaru

The paper develops AAV vectors with endothelial-specific tropism for brain delivery in rodents and broad tropism in primates, demonstrating their utility in genetic engineering of the blood-brain barrier.

bioRxiv · Jan 12, 2023Bioengineering

Broad gene expression throughout the mouse and marmoset brain after intravenous delivery of engineered AAV capsids

N. C. Flytzanis, N. Goeden, D. Goertsen, A. Cummins, J. Pickel, V. Gradinaru

The paper identifies AAV capsid variants that target the brain with high specificity and avoid liver expression in mice and marmoset non-human primates.

bioRxiv · Jun 16, 2020Bioengineering