Aberrant CD4+ T cell refeeding response impairs neuro-immune crosstalk in Parkinson's disease
Karl Austin‐MuttittiD, Bethan R DavidiD, Martina SassiiD, Ravi Agarwal, Thaís S. SabedotiD, Jeffrey R. JonesiD, Michael S. CuocoiD, Benjamin J. JenkinsiD, Luke D. RobertsiD, Leo Harris, Natalia Kieronczyk, Gang Han, Matthew D. HitchingsiD, Paul C. DonaghyiD, Alison Jane YarnalliD, Catherine A. ThorntoniD, Biju MohamediD, Alwena H. MorganiD, F. Thomas, Nicholas JonesiD, Fred H. GageiD, Jeffrey S. DaviesiD
Abstract
T cells modulate disease associated neuroinflammation in Parkinsons disease (PD). We report that circulating CD4+ T cells from people with PD have a dysregulated transcriptional and cytokine response to fasting and refeeding and an altered metabolic profile. The CD4+ T cell secretome mediates a metabolic program in neurons that is impaired in PD, revealing dysfunctional neuro-immune signalling that may contribute to disease pathology.
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