Enhanced immunogenicity of a Clostridioides difficile TcdB vaccine adjuvanted with a synthetic dual-TLR ligand adjuvant.
Farha NaziD, Nicholas Hagspiel, Feifan Xu, Brandon A. ThompsoniD, G. Brett MoreauiD, Mary Young, Joel F. Herbein, Christopher B. FoxiD, William A. PetriiD, Mayuresh M. Abhyankar
Abstract
We report a comprehensive evaluation of the toxin B (TcdB) vaccine adjuvanted with a dual Toll-like receptor ligand liposome adjuvant for Clostridioides difficile infection (CDI). The vaccine completely protected mice from a lethal infection. Compared to alum adjuvanted TcdB, it generated functionally superior systemic antibodies and supported strong memory B cell and gut IgA responses. This pharmaceutically acceptable adjuvant platform holds promise for developing a next-generation CDI vaccine.
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