Comment to: "Topology of molecular deformations induces triphasic catch bonding in selectin-ligand bonds"
Abstract
We contradict diverse mathematical claims of a paper by Casey O. Barkan and Robijn F. Bruinsma in PNAS 2024, 121, No. 6, e2315866121, former BioRxiv preprint from Sept.12,2023. It deals with the physical mechanisms of protein-ligand catch bonding for the family of selectin proteins. Selectins exhibit slip, catch-slip, and slip-catch-slip bonding.
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