biophysical modeling

The paper uses quantitative modeling to show how hydrated polymer systems regulate oxygen delivery and reactive species buffering across biological processes, from amphibian development to human reproduction and disease.

This study determines the structure of the SufBC2D-SufE complex, revealing conformational changes that facilitate sulfur transfer in bacterial Fe-S cluster assembly.

This study presents cryo-EM structures of HSV-1 UL9 and elucidates its dimerization, origin recognition, and allosteric regulation by ICP8.

This study shows that microcystin (MC) in Microcystis aeruginosa enhances carbon fixation by activating the carbon-concentrating mechanism (CCM) and altering photosynthetic processes under fluctuating light conditions.

This study reveals that SpoIVA forms track-like polymers during bacterial spore development, with dimerization and ATPase activity playing distinct roles in its assembly and function.

This study identifies divergent CRD-dependent mechanisms by which RAS isoforms selectively recruit CRAF and ARAF, revealing how the CRD modulates RAS affinity and RAF activation.

The paper identifies Dafcin, a microprotein in Drosophila, which resembles the influenza HA fusion peptide and regulates yolk granule size by inducing negative membrane curvature.

This study identifies SOLAR as a lysosomal quality control pathway that links CASM to p62-driven membrane repair and redox signaling, with implications for aging and degenerative disease.

This study uses long-timescale molecular dynamics simulations to show that Ca2+ binding shifts pre-existing active states in Sorcin rather than inducing activation de novo.

This study identifies and characterizes 13 HvHMA genes in barley, revealing their diverse expression patterns and functional roles beyond heavy metal homeostasis.

The paper investigates the structure and dynamics of the archaeal ACDS complex, revealing a mechanism for efficient carbon transfer through transient interactions rather than stable complexes.

The paper identifies a novel allosteric pocket in KV1.3 that enables selective immunomodulator design, revealing a non-contact selectivity mechanism through structural analysis and inhibitor development.

This study identifies two novel biosynthetic intermediates and characterizes their enzymes in the unique glycan modification pathway of C. difficile flagellin.

This study shows that IgD's long hinge increases entropic cost in antigen binding, reducing negative selection and raising the threshold for germinal center entry.

The paper investigates the mechanism of proton-coupled transport in the mycobacterial Spns transporter using spectroscopy, modeling, and mutagenesis, revealing how protonation and substrate binding influence conformational states and transport directionality.

This study identifies nSMase2 as a metabolic tumor suppressor in breast cancer by restraining TAZ and inhibiting tumorigenesis.

The paper examines changes in chloroplast ribosomes during evolution from cyanobacteria to land plants, identifying structural features and protein modifications.

This study identifies a conserved dimerization mechanism in SF1A UvrD-family helicases, showing that the 2B domain mediates dimerization and activation across multiple species.

This study investigates how chromatin compaction affects retroviral integration by analyzing the interaction between intasomes and nucleosomes, revealing distinct strategies in HIV-1 and PFV.

This study shows that negative autoregulation in gene circuits enables stronger environmental switching by favoring alleles that create strong molecular switches in E. coli.

The paper identifies how cell heterogeneity and YAP1 inactivation drive tissue patterning during intestinal regeneration through feedback mechanisms.

This study shows that prolonged crowding induces an invasive phenotype in cancer cells through mechanomemory, mediated by membrane domain disaggregation under compressive stress.

This study investigates how the falx cerebri contributes to the splenium's vulnerability in traumatic brain injury using biomechanical simulations.

This study shows that the TIRR-53BP1 axis regulates PLK1 activity during mitosis, affecting chromosome segregation and kinetochore assembly.

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

This study identifies 41 novel viruses and 13 known viruses in predatory insects used for biocontrol, revealing potential interspecies viral transmission across trophic levels.

This study identifies a novel protein fold in KSHV ORF24 that enables direct binding to RNAPII CTD, facilitating viral late gene transcription through structural mimicry of a host transcription factor.

This paper uses native mass spectrometry to show BTK recruits to membranes via phosphatidylserine and is activated by PIP3, proposing a two-step mechanism for membrane recruitment and activation.

This study uses molecular dynamics simulations to show that membrane composition significantly affects the pKa of aminolipids in lipid nanoparticles, influencing their pH-dependent behavior and membrane remodeling.

This study identifies an enzymatically inactive chromatin binding mode of PARP1 that compacts undamaged chromatin without triggering catalytic activation.