experimental assay

This study evaluates genetic variation in maize's response to chilling stress and recovery, identifying heritable traits linked to cold resilience.

The paper investigates parasite infections in Nile tilapia aquaculture, finding that monopisthocotylan parasites are prevalent and linked to gill lesions, while stakeholders rarely identify parasites as a health cause.

The paper identifies sex-specific transcriptional differences in specific cell types of the human subgenual anterior cingulate cortex and links them to GPCR signaling differences in mice.

This study shows that evolution can restore cellular function without conserving microscopic organization, leading to novel molecular phenotypes in budding yeast.

This paper identifies a binuclear [Cu2S2] cluster in DPOR that mediates functional asymmetry between its active sites.

The paper introduces an open-access virtual navigation task compatible with neuroimaging, demonstrating its use with EEG and behavioral tracking in human participants.

The paper identifies detergent LMNG as stabilizing a weak FZD-G protein interface, revealing that FZDs inherently weakly couple to G proteins and preferentially signal through DVL.

The paper reconstructs the asperosaponin biosynthesis pathway in Dipsacus asperoides by integrating genomics, transcriptomics, and biochemical analyses, revealing gene family diversification and glycosylation order.

The paper identifies promoter hypomethylation as a driver of transcriptomic plasticity and aberrant gene expression in colorectal cancer, linking it to distinct cell states and metastatic behavior.

This study identifies clinical, biochemical, and radiographic features of ECHS1 deficiency through a multi-center retrospective analysis of 113 patients, highlighting differences in onset and outcomes across age groups.

The paper identifies prokaryotic homologs of the major vault protein that assemble into vault nanocapsules, revealing structural and size variability.

This study shows that temperature affects Culex tarsalis vector competence, tissue bottlenecks, and gene expression in response to West Nile virus infection.

The paper shows that MurJ, a Lipid II flippase, dynamically coordinates bacterial growth and division by transiently capturing at division sites during septal synthesis.

The paper shows RNA polymerase backtracking promotes type III-A CRISPR DNA targeting by inhibiting GreA anti-backtracking factors, which suppress Cas10-Csm activity.

This study compares the susceptibility and molecular responses of three nematode species to the nematode-trapping fungus Arthrobotrys oligospora, revealing species-specific differences in behavior and gene expression.

This study shows Orsay virus infection reduces locomotion in C. elegans and alters food choice based on sensory context, with eol-1 modulating these behaviors.

This study identifies Jade1S as a SUMO ligase and chaperone that regulates tau stability, prevents oligomerization, and promotes proteasomal degradation of aggregated tau.

The paper identifies succinate as a mediator of interbacterial antagonism in the oral microbiome, showing how metabolic interactions among commensals regulate pathobiont expansion through pH modulation.

ClearGel enables chronic, near-millimeter two-photon imaging through the intact skull in live mice with high resolution and reversibility.

This study compares age-specific pediatric EEG templates to adult templates and finds they better match individual MRI-based biomarkers in children up to 12 years old.

This study evaluates polymerase and primer biases in ultra-long-read metabarcoding for soil eukaryotes, finding that certain polymerases and primer pairs improve data quality and biodiversity recovery.

This study investigates how humans detect relative speed differences in motion-based figure-ground segregation, finding an asymmetry where slower targets are harder to detect than faster ones, influenced by background speed and motion reliability.

The paper quantifies phosphoform organization near β2 integrins and shows that signaling alters phosphosites while preserving spatial organization of proteins.

This paper describes a workflow for dual-guide CRISPR-Cas9 editing of Pla2g6 in mouse BMDMs, showing high editing efficiency and specific deletion patterns.

This study examines how Clcn7 mutations in mice affect bone phenotypes, showing increased trabecular bone mass with variations based on age, sex, genetic background, and mutation type.

This study identifies MoALE1, an ART-like effector in Magnaporthe oryzae, which suppresses host immunity and enhances rice blast pathogenicity.

This study identifies contrast sensitivity as a key perceptual constraint affecting collision risk for Bearded Vultures with human-made aerial structures.

The paper uses lineage tracing and single-cell RNA sequencing to show that rhabdoid tumors converge on a limited set of transcriptional states despite clonal diversity.