Liedewij Laan

This study shows that evolution can restore cellular function without conserving microscopic organization, leading to novel molecular phenotypes in budding yeast.

The paper quantifies Cdc42 polarization dynamics in budding yeast using live cell microscopy and mesoscale observables, revealing stage-specific characteristics and differences in genetic backgrounds.

This paper introduces a Sortase A-based method to farnesylate Cdc42 in vitro, enabling efficient and reproducible prenylation for biochemical studies.

This study demonstrates plasmonic enhancement of protein function in living cells by coupling designed nanoparticles to Archaerhodopsin proteins, increasing fluorescence and response speed.

This study shows that compensatory mutations in yeast rewiring gene fitness across cellular processes, not just individual genes, highlighting the role of functional overlap and network interconnectedness.

The paper describes the use of GTPase Glo assays to quantify GTPase cycling rates and interactions with effector proteins.

The paper develops a bottom-up model of yeast polarity genotype-phenotype map to predict evolutionary relevant phenotypes by integrating mechanistic and noisy data.