structural biology

This study presents cryo-EM structures of active H/ACA snoRNPs, revealing inter-protomer interactions and how mutations affect pseudouridine formation and ribosome biogenesis.

This study investigates the minimal NHEJ system in M. tuberculosis using structural simulations, assays, and single-molecule analysis, revealing Ku-LigD interactions and their impact on enzymatic activity.

This study investigates the structural and biochemical regulation of PP2A(B55) by ENSA, revealing how pENSA inhibits the enzyme and provides insights for inhibitor development.

The paper introduces an efficient RNA folding model that accurately simulates RNA hairpin unfolding and reproduces experimental thermodynamic properties.

The paper introduces a subject-specific cortical folding model that generates fiber orientations from cortical geometry, validated with fetal MRI and applied to adult data without diffusion inputs or machine learning.

This study presents a modeling framework simulating nuclear transport at full amino-acid resolution, revealing the dynamic FG-meshwork and role of Nsp1 and NTRs in transport.

This study presents the first crystal structure of HtpGMtb, revealing a conformationally silent dimer and direct TLR4 interaction, providing insights into its catalytic activity and TLR4 activation mechanism.

This study characterizes HLp, a bacterial histone that forms tetramers and wraps ~60 base pairs of DNA, revealing a new mode of histone-DNA interaction in bacteria.

This study reveals the conformational dynamics of Tom70 through structural and computational analyses, showing how its allosteric network coordinates mitochondrial protein import and is modulated by viral interactions.

This study examines how glycan evolution in H3 hemagglutinin affects antigenicity and immunogenicity, showing reduced antibody binding and shifted immune response.

This study uses SAXS and simulations to show that protein hydration shells shrink with increasing temperature, revealing temperature-sensitive structural changes in the hydration shell.

This paper elucidates how anaerobes regulate nitrogenase activity through the PII-protein couple NifI1 and NifI2, revealing a structural mechanism for energy-dependent N2-fixation control.

This paper identifies a β-sheet stabilization mechanism in the island domain of LRR-RPs that mediates ligand binding and co-receptor recruitment, revealing insights into plant immune signaling activation.

This study characterizes the Ec78 retron system, revealing its dual-enzyme effector complex and the molecular mechanism of phage clearance through cryo-EM structures and functional analysis.

The paper uses structural modeling and experimental analysis to reveal how CBP and ChiS regulate chitin utilization in Vibrio cholerae through an allosteric switch mechanism.

The paper determines the structures of SK2 channels in different states and identifies how apamin and small molecules modulate their gating.

The paper determines the structure of tRNA-bound CRISPR-Cas13 and reveals universal HEPN RNase mechanisms for substrate recognition and catalysis.

The paper re-analyzes the crystal structure of PDE3B bound to GSK4394835A, revealing it as a reversible covalent inhibitor through boronate anion formation.

This study reports the crystal structure of a light-activated maize CRY1c-ZmGL2 complex, revealing its role in regulating cuticular wax biosynthesis through structural and biochemical analysis.

This paper identifies Saponarin as a broad-spectrum antiviral compound targeting coat proteins of multiple banana viruses through in silico methods.

This study uses machine learning and molecular dynamics to design potent allosteric inhibitors for mutant EGFR, identifying 10 novel compounds more effective than existing ones.

This study determines the structure of HAstV spikes bound to FcRn, identifies conserved epitopes, and suggests repurposing FcRn inhibitors for antiviral therapy.

The paper determines the binding modes of three isoxazolyl penicillins to a class-A beta-lactamase at near physiological temperatures using crystallography.

This study shows human spastin functions as an ATPase-independent microtubule nucleator by forming ring-stack structures, redefining its role in microtubule dynamics and HSP pathology.

This study investigates how lipid membrane interactions affect the conformational dynamics and energy landscape of membrane-bound TNF, showing that membrane association stabilizes the symmetric state over asymmetric conformations.

This study identifies the structural basis of allosteric regulation in the human cis-prenyltransferase complex using a combination of experimental and computational methods.

The paper identifies a conserved carotenoid-binding site in heliorhodopsins, revealing their role in light harvesting through exogenous xanthophyll recruitment due to inverted membrane topology.

This paper reports the crystal structures of TMEM55B and its complex with a RILPL1 peptide, revealing a conserved TBM motif that mediates adaptor recruitment to lysosomes.

This study identifies four antibody mechanisms that disrupt FimH-mediated bacterial adhesion by altering its conformation and glycan binding.

The paper proposes the Texas 2-Step model to explain how YcgR modulates flagellar motor rotation in E. coli by interacting with MotA and FliG through conformational changes.