structural biology

This study characterizes the structural evolution of Fcα/μR-mediated antibody recognition across vertebrates by analyzing duck and mouse Fc/R interactions with IgM and IgA.

This paper introduces SHARP, a method using cosmological web analysis to characterize brain ageing and cognitive impairment by analyzing MRI data from CamCAN and OASIS-3.

LinearKnot approximates CParty's hierarchical pseudoknot analysis with linear time complexity, achieving comparable accuracy for RNA structure prediction and ensemble calculations.

The paper predicts a cohesin acetylation complex in budding yeast that interacts with nicked DNA and confirms its function through experiments.

This study identifies the endothelial protein C receptor (EPCR) as the entry receptor for Langya virus and reveals the molecular basis of its interaction with the viral attachment glycoprotein.

This study uses MAS NMR to determine the binding mode of HRF-4467, a second-generation HIV-1 maturation inhibitor, in the CA-SP1-NC11 complex with IP6, revealing its mechanism of action and resistance profile.

The paper identifies prokaryotic homologs of the major vault protein that assemble into vault nanocapsules, revealing structural and size variability.

This paper evaluates how site heterogeneity affects brain-phenotype predictions in multi-site data, finding that larger sample sizes improve accuracy more than multi-site composition.

The paper shows that coarse-grained connectome partitions can preserve functional predictions about neural activity even when path structure is lost.

FoXSight identifies weak binding events in crystallographic fragment screening by detecting target-specific density features in noisy electron density maps.

This paper extends a protein structure validation method to RNA, showing it can detect errors in low-resolution structures where map-based methods fail.

The paper investigates how the Spiral-Pincer scaffold regulates ATM kinase activation by oxidative stress, showing it restricts access to an oxidation-competent conformation.

This study investigates coenzyme specificity in yeast GDH3, showing how mutations alter coenzyme preference and revealing structural and evolutionary mechanisms of coenzyme regulation.

The paper investigates how SCN- induces prestin contraction through structural changes in its dimers and monomers, associated with altered intermonomer angles and beta sheet loss.

The paper develops a pipeline to estimate structural and functional connectomes from lesion masks to predict post-stroke recovery outcomes, showing better performance than traditional methods.

BundleMorphometry quantifies local white matter bundle shape using nonlinear registration, revealing deformation patterns in glioma and Parkinson's disease datasets.

This study identifies distinct peripheral elements in senataxin that mediate R-loop unwinding and RNA polymerase II regulation through structural and biochemical analyses.

The paper shows functional MRI eigenmodes can approximate specific receptor and transporter distributions in the cortex, while structural and geometric eigenmodes cannot, and applies this to detect molecular differences in autism and schizophrenia.

This paper introduces BL8, a structural language to evaluate deep learning predictions of antibody-antigen interactions, revealing false positives and enabling reliable consensus predictions.

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

The paper analyzes the structural and functional interactions of HERC2/UBE3A and HERC2/DOCK10 complexes to understand their role in Angelman and Dup15q Syndromes.

The paper investigates how ZEB85 activates TrkB by identifying a sulfotyrosine motif essential for agonist activation, while BDNF uses a different binding site.

The paper presents structures of hTRPC3 in resting and open states, revealing how the moonwalker mutation activates the channel by disrupting a polar interaction and inducing structural changes.

This study examines how mutations in the N-terminal domain of SARS-CoV-2 Spike affect antigenic properties and immune escape, finding that structural flexibility and loss of heme-metabolite interaction reduce antibody neutralization.

This paper describes a trimeric inhibitor, S22, that stabilizes the SARS-CoV-2 spike protein in a closed conformation, preventing ACE2 binding and viral entry.

SMARTFlexDB links ligand-bound and ligand-free RNA structures to study conformational flexibility and small-molecule recognition, providing a resource for RNA-targeted drug discovery.

The paper determines the structure of Llp and analyzes the FhuA:Llp complex to understand superinfection exclusion in bacteriophage T5.