cancer & tumor microenvironment

The paper shows that additive gene effects underlie Mendelian inheritance and contribute to heterosis by analyzing genotypic and phenotypic data from four genes.

This paper extends Mendelian randomisation to founder-haplotype data in Diversity Outbred mice, showing founder-effect patterns improve causal inference compared to scalar coding.

This study assesses cancer risk and survival in POT1 variant carriers across multiple biobanks and finds increased cancer incidence but no increased mortality.

This study designs gene regulatory networks to slow somatic evolution in simplified multicellular organisms and identifies tradeoffs between network robustness and fitness.

The paper identifies a conserved profibrotic transitional state arising from alveolar and airway progenitors in fibrosis and shows its epigenetic regulation.

The paper investigates how intron lariats, especially those with transposable elements, trigger immune responses in cancer cells and shows that RNA editing and DBR1 depletion can be used to enhance anti-tumor effects.

This study shows hypoxia induces LARP1-driven stress granules that protect mRNAs from decay, sustaining mitotic progression in cancer cells.

This study shows that targeting REV1 in colorectal cancer enhances chemotherapy sensitivity in a context-dependent manner and inhibits organoid growth.

The paper investigates how neural circuits in the primate frontal cortex support compositional generalization by separating computations into spatial and temporal components and identifying biases when these components are misaligned.

This study shows chronic sleep disruption causes distinct transcriptional and proteomic changes in brain compartments, particularly affecting synaptic function and potentially contributing to Alzheimer's risk.

This study identifies chromothripsis as a common driver of pleural mesothelioma, linked to gene deletions and poor patient survival.

This study investigates metabolic complexity in the human brain using PET and fMRI, finding that metabolic entropy correlates with network metastability and declines with age.

This study shows HER3 drives glycolysis in liver metastases of CRC and PDAC, and HER3 inhibition increases OXPHOS dependency, which can be targeted with combined therapy.

This study identifies a functional interaction between PDS5A and TOP2B at CTCF-bound chromatin sites, showing their cooperative recruitment and impact on gene expression and chromatin structure in gliomas.

The paper shows early NOTCH1 mutations are selected in normal tissue but suppress later cancer driver mutations through epistasis, highlighting stage-specific mutation effects in esophageal cancer.

This paper introduces Reinforcement Failing, an AI framework that identifies emergent spatial dynamics in adaptive tumor therapy by refining training environments.

This paper compares the mechanisms driving lesion outcomes in lung tumors and tuberculosis granulomas using agent-based models to study immune-tumor interactions and treatment responses.

This study shows that better adherence to the DASH diet in midlife and early elderhood improves late-life verbal memory and brain health through structural and neurovascular mechanisms.

This study shows that punctuated mutagenesis in cancer enhances adaptation by facilitating crossing of fitness valleys through clustered mutations.

The paper shows ecDNA localizes to the nuclear periphery in cancer, resisting silencing and enhancing transcriptional output through interactions with the nuclear lamina.

This study identifies SRPK1 as a key regulator of docetaxel resistance in prostate cancer by modulating splicing and apoptosis pathways.

This study shows that disrupting circadian rhythms through pluripotency factors and transcriptional pausing promotes cancer stem cell enrichment in TNBC, correlating with poor patient outcomes.

This study identifies a developmental GAL1-glycan program that promotes early breast cancer dissemination and metastasis by reactivating mammary stem cell traits and epithelial plasticity.

The paper shows that NF-kB and RAS signaling pathways are incompatible in B-cell leukemia, with NF-kB suppressing RAS-driven oncogenesis through developmental signaling constraints.

The paper shows that GALA, a process relocating GALNTs to the ER, enables co-translational O-glycosylation in pancreatic cancer, expanding the O-glycoproteome and promoting tumor growth.

This study shows TFEB regulates endosomal membrane fluidity and cargo trafficking, affecting cell migration and adhesion in bladder cancer.

This study identifies Streptococcus anginosus as a gastric cancer driver that uses a chromatin remodeler to reprogram host epigenomes and promote immune evasion.

This study identifies the CD109-SMURF2 axis as a mechanism that prevents EGFR degradation, sustaining oncogenic signaling and promoting SCC invasion and stemness.

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.