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- BioinformaticsbioRxivPreprint
Metaxa: A Transformer-Based Deep Learning Model for Taxonomic Classification of Long Nanopore Reads
Krešimir Friganović, Dominik Stanojević, Po-Shen Benson Chen, Mile Šikić
Metaxa is a transformer-based model for classifying long Nanopore reads, outperforming existing tools on out-of-sample data and across different sequencing chemistries.
DOI 10.64898/2026.04.20.719780 - BioinformaticsbioRxivPreprint
Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models
Alena Aspidova, Yuri Kuratov, Artem Shadskiy…·Veniamin Fishman
This paper adapts a modernized BERT-style model to genomic sequence modeling, achieving strong efficiency and performance, and releases it as an open baseline.
- PaleontologyJournal of genetics and genomics/Journal of Genetics and GenomicsPeer-reviewed✦ In-depth digest
Rapid and robust sex determination from ancient enamel proteomes using protSexInferer
Fan Bai, Zhongyou Wu, Xia Song, Qiaomei Fu
Using the share of AMELY-specific among all sex-specific amelogenin peptides (RAMELY), enamel proteomes are sexed consistently across four search engines, tolerating false-positive AMELY hits without manual checks.
1 citation - BiophysicsActa Crystallographica Section D Structural BiologyPeer-reviewed
A cryo-EM processing pipeline for microtubules using CryoSPARC
Daniel X. Zhang, Hugo Muñoz-Hernández, Pavel Filipčík…·Michal Wieczorek
The paper introduces MiCSPARC, a cryo-EM pipeline for microtubule structure determination, achieving high-resolution reconstructions of decorated and undecorated microtubules.
2 citations - NeurosciencebioRxivPreprint
Task-induced topological and geometrical changes in whole-brain dynamics predict cognitive individual differences
Ruiqi Chen, Hayoung Song, ShiNung Ching, Todd Samuel Braver
This paper develops a computational framework to model how task-induced changes in brain dynamics relate to cognitive individual differences using rsfMRI and tfMRI data.
DOI 10.64898/2026.04.19.719533 - BioinformaticsbioRxivPreprint
BioEngine: scalable execution and adaptation of bioimage AI through agent-readable interfaces
Nils Mechtel, Hugo Dettner Källander, Songtao Cheng…·Wei Ouyang
BioEngine enables biologists to run, adapt, and deploy bioimage AI models on various hardware by interacting with an AI agent through a user-friendly interface.
DOI 10.64898/2026.04.19.719496 - BioengineeringbioRxivPreprint
Scaling Multiplex qPCR Primer Design to 1000-plex using the Degenerate Incomplete Multiplex Primer List Extension (DIMPLE) Algorithm
Alessandro Pinto, Xue Dong, Wei Wu…·Xi Zhang
The paper introduces DIMPLE, a scalable qPCR primer design algorithm that enables 10,000+ primers in a single reaction, achieving low VAF detection and multiplex applications.
DOI 10.64898/2026.04.17.719221 - Cell BiologybioRxivPreprint
FlowWeb, a free, web-based platform for flow cytometry data analysis
Menno ter Huurne, Rustem Salmenov, Amit Mandoli
FlowWeb provides a web-based platform for flow cytometry analysis, offering automated workflows and visualization tools comparable to commercial software.
DOI 10.64898/2026.04.16.717288 - NeuroscienceScientific DataPeer-reviewed
A Virtual Reality Dataset to Support Hand Action Observation in Rehabilitation and Motor Learning Studies
Alessandro Ciraolo, Emilia Scalona, A. Zilli…·Maddalena Fabbri‐Destro
The paper presents a VR dataset of 33 upper limb gestures for VR-AOT, designed to support standardized and flexible implementation in neurorehabilitation and motor learning.
DOI 10.1038/s41597-026-07252-w - BiochemistryAnalytical ChemistryPeer-reviewed
The CcpNmr Analysis Simulated Metabolomics Database (CASMDB): An Open-Source Collection of Metabolite Annotation Data for 1D 1H NMR-Based Metabolomics
Morgan W. Hayward, Luca G. Mureddu, Gary S. Thompson…·Geerten W. Vuister
The paper describes the creation of CASMDB, a database of metabolite annotations for 1D 1H NMR-based metabolomics, enabling accurate simulation and visualization of spectra.
3 citations - GenomicsbioRxivPreprint
REPLAY: A reproducible and user-friendly application for DNA replication timing analysis from Repli-seq data
Quinn Dickinson, Chuanhe Yu, Juan Carlos Rivera‐Mulia
REPLAY automates DNA replication timing analysis from Repli-seq data, providing a reproducible and user-friendly tool without requiring programming expertise.
DOI 10.64898/2026.04.16.719037 - GenomicsbioRxivPreprint
Dibenzocyclooctyne-modified PCR primers enable direct enzyme-free click chemistry ligation for custom nanopore amplicon sequencing
Patrick Lypaczewski, B. Jesse Shapiro
The paper introduces DBCO-modified PCR primers for enzyme-free click chemistry ligation in nanopore amplicon sequencing, achieving higher pore occupation and reads than commercial solutions.
DOI 10.64898/2026.04.18.719403 - BioinformaticsbioRxivPreprint
A comparison of four proteomics software for hair proteome analyses
This study compares four proteomics software tools for hair proteome analysis, finding differences in peptide identification, protein inference, functional annotation, and quantification across tools and extraction methods.
DOI 10.64898/2026.04.17.719199 - Developmental BiologybioRxivPreprint
KELPE: knock-in exchangeable dual landing pad embryonic stem cells enable efficient screening of synthetic gene circuits
Aisling R. Fairweather, Yana Slavova, Mattias Malaguti
The paper introduces KELPE, a cell line with dual genomic landing pads for efficient screening of synthetic gene circuits in pluripotent stem cells.
DOI 10.64898/2026.03.22.713470 - BioinformaticsbioRxivPreprint
TernTables: A Statistical Analysis and Table Generation Web Interface for Clinical and Biomedical Research
Joshua D. Preston, Helen Abadiotakis, Ailin Tang…·Joshua L. Chan
TernTables automates clinical data analysis and table generation, using statistical rules and transparency tools to improve reproducibility and reduce administrative barriers in biomedical research.
- GeneticsbioRxivPreprint
EasyCAPS: A web tool for restriction-based genotyping and rational CRISPR-Cas9 donor design
Lucas Souza de, Jeferson Gross, Ana Paula Jacobus
EasyCAPS is a web tool that integrates dCAPS primer design with CRISPR-Cas9 strategies to improve genotyping and gene editing efficiency.
DOI 10.64898/2026.04.17.719238 - BiophysicsbioRxivPreprint
CGAgentX: Agentic AI Framework to Develop Transferable Coarse-Grained Models
Swarnadeep Seth, Sanket A. Deshmukh
CGAgentX develops transferable coarse-grained models using an agentic AI framework with specialized agents that autonomously optimize parameters to match experimental and simulation data.
DOI 10.64898/2026.04.17.719081 - BioinformaticsbioRxivPreprint
Relative Index of Chimeric Expression (RICE) Analysis: A Quantitative Approach for Chimeric RNAs Using FusionBlaster
Samuel Haddox, Yuhang Mao, Anam Tajammal…·Hui Li
The paper introduces RICE, a method to quantify chimeric RNA expression, validates it with qPCR and siRNA, and applies it to prostate cancer data to identify differentially expressed chimeric RNAs.
1 citation - Molecular BiologybioRxivPreprint
Detecting misfolded non-covalent lasso entanglements in protein structures, simulation trajectories, and mass spectrometry data
Ian M. Sitarik, Yang Jiang, Hyebin Song, Edward P. O’Brien
The paper introduces EntDetect, a tool to detect non-covalent lasso entanglements in protein structures, simulations, and mass spectrometry data, and demonstrates its application in identifying misfolded states.
DOI 10.64898/2026.04.15.718775 - BioinformaticsbioRxivPreprint
Virtual multiplex staining of the pancreatic islets across type 1 diabetes progression using a Schroedinger bridge
Ye Shen, Won June Cho, Saurabh Joshi…·Ashley L. Kiemen
This paper introduces SMILE, a diffusion model for converting H&E stains to multiplex IHC images, showing superior performance in pancreatic islet analysis and breast cancer stain conversion.
- Systems BiologyScientific ReportsPeer-reviewed
Network Ontology Transcript Annotation Identifies Genetic Signals Underlying Sex Determination.
Leonardo R. Orozco, Audrey E. Weaver, Daniel Jacob Klee…·Nolan C. Kane
The paper uses Nota to identify genes involved in cannabis sex determination by analyzing transcriptomic data from silver-treated plants.
5 citationstop 1% - BioinformaticsJournal of Proteome ResearchPeer-reviewed
NetMHCIIphosPan: a machine learning tool for predictingHLA class II antigen presentation of phosphorylated peptides.
Heli M. Garcia Alvarez, Saghar Kaabinejadian, Hooman Yari…·Morten Nielsen
NetMHCIIphosPan predicts HLA class II antigen presentation of phosphorylated peptides using immunopeptidomics data, outperforming existing tools.
3 citationstop 3% - Systems BiologyBioinformaticsPeer-reviewed
NAViFluX: a visualization-centric platform for interactive analysis, refinement and design of genome-scale metabolic networks
Manjunatha Beduru Krishnamurthy, Pasupula Sridhar Harish, Abhishek Subramanian
NAViFluX is a web-based platform for analyzing and designing genome-scale metabolic networks, enabling interactive visualization, refinement, and flux analysis of metabolic models.
1 citation - Synthetic BiologybioRxivPreprint
ADAR-Sense: an open-access, species-agnostic web tool for automated, user-customisable ADAR-based RNA sensor design
Henry Sserwadda, Kyemyung Park, Yong-Hee Kim…·Chung‐Gyu Park
ADAR-Sense is a web tool for designing ADAR-based RNA sensors with customizable parameters, enabling efficient and flexible sensor creation for various applications.
DOI 10.64898/2026.04.16.719097 - BioinformaticsbioRxivPreprint
GANGE: Achieving Sequencing Without Sequencing With Diffusion Guided Generative Genomic Transformer
Sagar Gupta, Anchit Kumar, Umesh Bhati, Ravi Shankar
GANGE is a deep-learning system that generates accurate genomic sequences from low-coverage, error-prone reads, reducing sequencing costs and enabling regulomics research without genome data.
DOI 10.64898/2026.04.15.718133 - EcologybioRxivPreprint
Overcoming software bottlenecks for scalable passive acoustic monitoring: insights from a global expert assessment
Martino E. Malerba, Kristian Bell, Maria M Palacios…·Cristian Pérez‐Granados
This paper identifies key challenges in passive acoustic monitoring software through expert assessment and proposes strategies to improve scalability and usability.
- NeurosciencebioRxivPreprint
The Incremental Cluster Threshold-Free Cluster Enhancement Algorithm for Functional Connectivity Analysis
Fabricio Cravo, Raimundo X. Rodriguez, Alfonso Nieto-Castañón, Stephanie Noble
The paper introduces IC-TFCE, an algorithm that improves the computational efficiency of threshold-free cluster enhancement for functional connectivity analysis, achieving significant speedups for large-scale analyses.
DOI 10.64898/2026.04.06.716826 - BioinformaticsbioRxivPreprint
Track Display Jockey (trackDJ): a user-friendly R package for visualization of epigenomic data
trackDJ is an R package that simplifies the creation of publication-quality epigenomic figures through a user-friendly interface and high-level plotting functions.
DOI 10.64898/2026.04.15.718328 - BiophysicsbioRxivPreprint
Transforming macromolecular structures into simulations of self-assembly with ioNERDSS
Yue Moon Ying, Mankun Sang, Gabriel Au…·Margaret E. Johnson
The paper introduces ioNERDSS, a Python tool that converts 3D atomic structures into coarse-grained models for simulating macromolecular self-assembly.
DOI 10.64898/2026.01.27.702082