synaptic & neural circuits

This study uses a fully coupled EMI model to investigate extracellular stimulation and ephaptic coupling in Purkinje and pyramidal neurons, showing how external fields affect neural activity and synchronization.

The paper investigates spatial memory distortions across different environments and time scales, finding systematic non-Euclidean patterns that support the cognitive graph hypothesis over the cognitive map hypothesis.

This study uses a neural field model to show that neuromodulatory systems dynamically gate cortical wave propagation by altering gain and spatial patterns of activity.

The paper analyzes finger joint kinematics using a biomechanical hand model and motion capture, finding task type primarily affects movement metrics while frequency impacts speed and harmonic distortion.

This paper harmonizes 2D and 3D immunofluorescent cell shape datasets using generative AI to create synthetic cells for machine learning and in silico studies.

The paper demonstrates that a modified ISRIB analog selectively targets a mutant eIF2B, improving synaptic plasticity and memory in mice, confirming its on-target mechanism.

This study introduces a tri-trophic model to explore how vegetation patterns and trophic interactions influence desertification transitions and ecosystem resilience.

This study reveals that iterative Bayesian inference explains the spatiotemporal dynamics of natural scene segmentation by integrating visual inputs with spatial priors.

In musical dyads, perturbing breathing disrupts both respiratory and auditory-motor synchronization whereas perturbing tapping disrupts only behavior, demonstrating a unidirectional causal influence from respiration to behavioral coordination.

This paper presents a VR system integrated with wearable MEG that enables whole-brain recordings during naturalistic behaviors.

This study shows human and non-human primate sleep timing is synchronized with lunar and solar gravitational cycles, independent of light exposure.

This paper develops a graphene-based electrode with hybrid encapsulation for chronic nerve stimulation and recording, showing improved stability and performance in vivo.

Real rummy-nose tetras follow a projected, anamorphically rendered virtual conspecific in a low-cost open-source 3D-tracked VR bowl, largely matching its speed and depth; a moving sphere elicits weak following.

The paper improves an optogenetic silencer for axonal inhibition, showing enhanced performance and axonal targeting in mouse models.

The paper measures temperature changes in mouse hippocampal slices during high-frequency stimulation, showing that synaptic activity increases local temperature.

This paper develops a biohybrid scaffold using functionalized silk fibroin to enhance charge-transfer efficiency, promoting neurite outgrowth in dorsal root ganglion neurons under electrical stimulation.

This study shows that repeated optogenetic activation of dopamine neurons induces locomotor sensitization and cross-sensitization to cocaine, demonstrating dopamine's role in behavioral plasticity.

This study shows that acetyl-CoA availability, regulated by AT-1, affects neuronal metabolism, growth, and synaptic activity in mice.

This paper develops an agent-based model to simulate multiple sclerosis progression and evaluates therapeutic strategies targeting oligodendrocytes and the blood-brain barrier.

The paper identifies excitation-inhibition interactions in fireflies that mediate flash synchronization through phase-response curve analysis and modeling.

This paper combines adaptive laboratory evolution and machine learning to engineer a methylsuccinate module for synthetic C1 metabolism in E. coli, achieving growth in three weeks versus six months with evolution alone.

This study examines how infusion location, rate, and anesthesia affect CSF tracer dynamics in mice using Gd-DTPA and MRI.

The paper uses consumer-resource models parametrized from monoculture exometabolite data to predict and design synthetic microbial consortia, revealing the importance of cross-feeding interactions and nonlinear dynamics.

This paper introduces a thermodynamics-first approach to molecular computation using the TBN model, demonstrating systems that perform Boolean logic and concatemer synthesis.

This study identifies synaptic mitochondrial oxidative stress as a driver of individual variability in age-related cognitive decline in mice, showing that targeting mitochondria with MitoQ reduces cognitive decline.

The paper introduces a new group-based operant task for mice, showing that repeated use leads to shifts in workload toward subordinates and rank consolidation.

The paper demonstrates neuromodulation in neural organoids using 3D shell MEAs, showing increased neuron firing rates with specific stimulation ranges.

The paper shows that auditory cortex deviance detection encodes the difference between internal predictions and sensory input, supporting the predictive coding framework.

The paper introduces MR-μScope, a system combining MRI and miniaturized microscopy to study neurovascular coupling across scales, showing vessel-size-dependent responses to stimuli.

This paper develops a biologically constrained spiking neural network to model neuromodulation effects on locomotor recovery after spinal cord injury, finding that reducing GABAergic inhibition improves movement coordination.