T-cell and B-cell Immunology

The paper shows that IgE memory responses are confined to lymphoid organs through GC IL-4 microniches, which are critical for IgE production during allergen recall.

The paper identifies BCL6 and CD4+ T cell dependence in generating functional IgM+ memory B cells independent of germinal center formation.

This study optimizes in vitro expansion of Vδ1+ γδT cells from nonhuman primate PBMCs using CD3 or PHA stimulation with cytokines and phospho-vitamin C, achieving high-fold expansions.

The paper introduces a dual-recombinase system for sequential mutagenesis in germinal center B cells, enabling FOXO1 knockout and subsequent re-expression to study its effects on class switch recombination.

This study shows that Ddx3x is essential for B-cell development in mice, with loss leading to developmental blocks and defects in immunoglobulin rearrangement.

This study identifies the murine dura mater as a transient niche for early-postnatal B lymphopoiesis, highlighting the role of CXCL12-expressing fibroblasts in supporting B cell development.

The paper develops a population dynamics model of B and TFH cells in germinal centers, showing reciprocal stimulation regulates their ratio and balances affinity maturation speed with B cell diversity.

This study analyzes T cell receptor repertoires in blood and tonsils, finding low clonal sharing and tissue-specific diversity, emphasizing the need for tissue-based analysis.

This study identifies L-phenylalanine as a metabolic checkpoint regulating Th2 cell development, energy metabolism, and function in allergy.

This study shows that NOG-hIL-4-Tg mice support human IgG production through IL-4-dependent B cell maintenance and class switching, with varying subclass responses and tertiary lymphoid structures.

This study identifies a BACH1-cMAF transcriptional axis that drives autoimmunity when SATB1 is lost, showing that targeting this axis can rescue disease.

The paper identifies a conserved set of transcription factors in human CD4+ T cell subtypes and shows subtype-specific rewiring of gene regulatory networks during activation and differentiation.

TIRTL-seq provides a scalable, cost-effective method for paired TCR repertoire sequencing, enabling accurate identification of TCR chain pairings and clonotype dynamics in large cohorts.

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.

This study shows that early-life antibiotic use reduces MAIT cell abundance, impairing immunity to pneumonia, but this effect can be reversed by reintroducing riboflavin-synthesizing commensals.

This paper develops a minimal energy-landscape model to explain how mechanical force affects T-cell activation by reshaping activation barriers and bond lifetimes through catch-slip dynamics.

This study investigates how intercalated cells interact with immune cells to maintain renal immune homeostasis and contribute to autoimmune kidney disease, identifying an IL-33-mediated Treg interaction.

The paper identifies cis-regulatory elements and transcription factors controlling FOXP3 expression in human Tregs and Tconvs, revealing mechanisms that restrict FOXP3 to Tregs in mice.

The paper investigates how B cell affinity affects germinal center (GC) responses by showing high-affinity B cells have shorter GC residence times and lower-affinity B cells are maintained, suggesting an antibody feedback mechanism that modulates affinity and epitope spreading.

The paper shows that intrathymic HSPC transplantation restores T cell development via ILC3-TEC interactions in a ZAP-70-deficient mouse model.

This study identifies diverse TCR repertoires in CD4+ MAIT cells, showing they use non-TRAV1-2 TCRs and may recognize alternative MR1 ligands.

This study develops J-DTR mice to deplete antibody-secreting cells with diphtheria toxin and analyze their differentiation kinetics.

The paper shows that antigen clustering on follicular dendritic cells enhances B-cell receptor activation through geometric control of tyrosine phosphatase exclusion.

This study identifies Sox4 as a suppressor of IL-10 production in Treg cells by degrading c-Maf, leading to exacerbated type 2 inflammation in asthma models.

The paper identifies distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation through varied interactions.

The paper evaluates the effects of Zap70 and Itk inhibitors on T cell activation and identifies novel phosphotyrosine targets using proteomics.

This study identifies proteostasis as critical for T cell differentiation potential and tumor-infiltrating lymphocyte function, showing that maintaining E3 ubiquitin ligases improves anti-tumor responses.

This study compares the effects of cytomegalovirus and rheumatoid arthritis on senescent CD4+ T cells using mass cytometry, finding distinct differentiation and functional profiles.

The paper measures how costimulatory and inhibitory signals affect LAT condensate nucleation timing after TCR activation.