T-cell and B-cell Immunology

A network of bZIP transcription factors and inhibitors enforces differentially proliferative and cytotoxic states in T cells

This study identifies bZIP transcription factors and inhibitors that influence T-cell proliferation and cytotoxicity under exhaustion conditions.

Intrinsic immune receptor triggering mechanism informs rational chimeric receptor design

The paper identifies CD3ε as a primary trigger subunit in TCR activation through phase separation with Lck, leading to the design of TRIG molecules that activate T and NK cells via endogenous receptor signaling.

A computational investigation of pathways for ex vivo differentiation and dysfunction of healthy and patient T cells

This paper uses mathematical models to investigate T cell differentiation pathways during ex vivo expansion, finding that differentiation is dynamic and not unidirectional, with implications for improving adoptive T cell therapy.

Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling

The paper shows that glutaminolysis and mitochondrial metabolism are conditionally crucial for B cell differentiation and cytokine signaling, revealing metabolic regulation of plasma cell generation and cytokine receptor signaling.

An ITK - SLP-76 Y173 Axis Regulates TCR Signal Persistence and Thymic Development

This study shows that the ITK-SLP-76 Y173 axis is essential for TCR signal persistence and thymic development, as its disruption reduces thymocyte cellularity and alters CD4/CD8 ratios.

Stimulation strategy matters: A B-cell focused single-cell transcriptomic study on in vitro stimulated immune cells

This study compares B-cell stimulation strategies using single-cell transcriptomics, finding distinct transcriptional responses and cell-cell interactions depending on the stimulation method and time.

Weaning imprints a hybrid cytotoxic-regulatory identity on intestinal CD4+ T lymphocytes

This study tracks intestinal CD4+ T cells from suckling to adulthood, showing they adopt a transient cytotoxic-regulatory state at weaning, influenced by microbiota and early-life commensals.

Donor-derived CD8+CD122+ Tregs generated in mixed donor chimeric NOD mice suppress autoreactive T cells

This study identifies donor-derived CD8+CD122+ Tregs in mixed chimeric NOD mice that suppress autoreactive T cells and may offer a new therapeutic strategy for autoimmune diabetes.

Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection

Conserved Brain-Associated CD8+ T Cell Programs and Their Regulation by the Brain Microenvironment

This study identifies conserved functional features of brain-associated CD8+ T cells in mice and marmosets and shows how brain signals regulate their effector programs.

TCR signal strength during positive selection shapes CD25 expression patterns on thymically derived regulatory T cells

HDAC5 tunes effector competence in differentiated human CD8+ T cells through an ACTL6A-IRF4 axis

This study identifies HDAC5 as a regulator of effector competence in human CD8+ T cells, showing it modulates cytokine responses and TCR activation through an ACTL6A-IRF4 axis.

Human lymph node CD8+ T cell memory is nested within drainage regions

The paper shows that human CD8+ T cell memory is nested within drainage regions, with shared repertoires among nodes within a region regardless of virus specificity.

Infection drives localised and individualised antibody repertoires, whereas immunisation promotes repertoire convergence in pig

This study compares antibody repertoires in pigs after infection and immunisation, finding infection drives compartmentalised, individualised responses while immunisation promotes convergent, public repertoires.

A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseases

This study profiles B cell activation states using multi-omics data to identify genetic mechanisms underlying immune-mediated diseases.

A computable probability landscape for T cell receptor repertoire sampling and comparison

The paper introduces BEAM, a probability model for TCRβ sequences that enables depth-aware sampling calculations and interpretable repertoire comparison.

Computational identification of responding T cell clones from longitudinal repertoire sequencing

This paper introduces CloneSearch, a method to identify expanding and contracting T cell clones from longitudinal TCR sequencing without requiring antigen-specific information.

Xist-mediated gene silencing promotes T cell-driven autoimmunity

This study shows that Xist-mediated gene silencing supports CD4+ T cell persistence and colitogenic capacity, contributing to autoimmunity.

A Multiclass Mechanistic Model of Vaccine-Induced Humoral Response

The paper develops a mechanistic model of vaccine-induced humoral responses, showing class-specific activation and competition among B cells, with stronger competition within classes.

Systemic Autoimmunity Remodels Microbiota-Reactive CD4⁺ T Cell Immunity

This study shows systemic autoimmunity expands and differentiates microbiota-reactive CD4 T cells, which exacerbate autoimmunity through IL-21 and IFN-gamma mechanisms.

ClonoDeconv: reference-based α - β paired recurrent clonotype proportion estimation from bulk-TCR sequencing

ClonoDeconv estimates paired TCR clonotype proportions from bulk-TCR sequencing using a single-cell reference, capturing longitudinal T-cell clonal dynamics.

IL-2 and CD40L can establish and sustain a human B cell-mediated immune regulatory network

This study identifies IL-2 and CD40L as key drivers of a B cell-mediated immune regulatory network by generating TIGIT+ CSM B cells that suppress inflammation and promote regulatory T cell responses.

Sustained antigenic engagement programs multidimensional CTL states with distinct cytotoxic capacities

This study shows that sustained antigenic engagement leads to multidimensional remodeling and functional diversification of CTLs, maintaining cytotoxic activity while creating functionally distinct states.

Atypical T cell receptor signalling permits distinct gut gd T cell responses to healthy versus dysregulated tissues

The paper identifies an atypical TCR signaling pathway in gut γδ T cells that limits activation in healthy tissues but allows full responses during tissue perturbation.

Germinal centers can persist for up to one year with declining somatic hypermutation and ongoing plasma cell output

This study tracks germinal center responses in rhesus macaques over a year, showing prolonged GCs with declining SHM and ongoing plasma cell production.

Fab Dimerization Crosslinks and Activates the γδ T-Cell Receptor

This study presents the structures of the Vγ9Vδ2 TCR in inactive and agonist-crosslinked states, revealing a dimerization-driven activation mechanism.

Antigen-aware TCR embeddings reveal conserved immune patterns for personalized immune monitoring

TCRmeta integrates antigen specificity with TCR repertoires to enable cross-individual and longitudinal immune monitoring by revealing conserved patterns and technical variation robustness.

Noncanonical CD11b on CD8+ T cells promotes cytotoxic effector function

This study identifies CD11b as a noncanonical marker of cytotoxic competence in CD8+ T cells, enhancing their antitumor activity in mouse and human tumors.

An ER Retrieval-and-Release System Reveals Ligand-Independent Basal Signaling by Cell Surface TCRs

The paper develops an ER retrieval-and-release system to study ligand-independent basal TCR signaling, finding that surface TCRs generate distinct phosphorylation patterns compared to ligand-induced activation.

Non-canonical IL-2 signaling facilitates peripheral regulatory T cell differentiation

This study identifies MACS as a non-canonical IL-2 signaling pathway that promotes Treg differentiation and function through AP-1-dependent mechanisms.