T-cell and B-cell Immunology

The paper identifies long-lived IgE plasma cells in the spleen that persist after immunization and contribute to sustained IgE responses in mice.

This study shows that B cells in human tonsils migrate locally during affinity maturation at a consistent rate, contributing to diversity while balancing selection.

This study identifies CDK1 as a key regulator of CD4+ T cell effector function through integrative multi-omics analysis, showing its role in linking phosphorylation to gene regulation and immune traits.

This study defines the dynamic activation-memory cycle of human IgG memory B cells through single-cell profiling, revealing distinct reactivation trajectories and functional roles in humoral immunity.

This study shows that dietary iron deficiency impairs memory T cell function after influenza infection, specifically reducing IFN-gamma production without recovery through dendritic cell co-culture.

The paper develops a 37-color spectral flow cytometry panel to analyze T cell phenotypes and cytokine expression in human intestinal samples, with applications in inflammatory bowel disease research.

The paper investigates how immunodominance affects CD8+ T cell differentiation and hierarchy after RNA vaccination, finding that dominant responses influence subdominant ones through cross-competition.

This study identifies the Bhlhe40-Pou2af1 axis as a transcriptional regulator of CXCR5 expression in Tfh cells, independent of the Bcl6-Blimp1 pathway.

This study shows glycolytic flux supports human Th1 cell identity and effector function through STAT1 O-glycosylation, with inhibition of glycolysis or O-glycosylation reducing IFN-gamma production.

This study shows OCA-B in T cells promotes ICI-induced autoimmunity but is not needed for anti-tumor immunity, suggesting it could be targeted to prevent autoimmunity without harming cancer treatments.

The paper analyzes gene expression in the pancreas of Aselli of the common shrew to assess its role in plasma cell differentiation and compares it to spleen and bursa of Fabricius.

The paper identifies regulatory T cells suppressing tissue-resident CD8+ T cell programs in early melanoma, revealing a mechanism of immune evasion.

This study identifies how ICT01 antibody activates Vγ9Vδ2 T cells by binding BTN3As, destabilizing BTN2A1-BTN3As interface, and promoting TCR engagement.

The paper shows that TCRs from Tregs are more effective than Tconv TCRs in driving pTreg differentiation, with distinct phenotypes based on antigen type.

This study shows that haem toxicity in the aged spleen impairs T-cell immunity through iron deprivation, and iron infusions can enhance vaccination responses in aged mice.

The paper constructs a single-cell GEX-TCR reference atlas and introduces TCR-DeepInsight, a deep-learning framework to characterize disease-associated TCRs.

The paper investigates phagocytic capacities of B cell subsets and their ability to present antigens to T cells, finding that only peritoneal cavity B1 cells can uptake non-cognate antigens but fail to activate T cells.

This study identifies MARK2 as a gatekeeper of CD28-dependent co-stimulation in T cells, showing it restricts metabolic and transcriptional programs normally driven by CD28.

This study profiles B cell development using single-cell RNA sequencing, revealing proliferative bursts after recombination and repertoire changes during lymphopoiesis.

The paper creates a searchable database of publications using fluorescent probes and flow cytometry to study antigen-specific B cells, showing increased research focus on pathogens like SARS-CoV-2 and HIV.

This study develops an in vitro model of terminal CD8 T cell dysfunction and epigenetic stabilization, revealing stable exhaustion signatures and impaired functionality.

This study shows that TCF1 expression drops before CD8 T cells divide, and this drop predicts their long-term fate as effectors or memory cells.

The paper develops bioengineered human tonsil organoids (BTOs) to study immune functions, showing they support antigen-specific responses and immune-stromal interactions comparable to native tissues.

The paper analyzes T cell responses to mRNA vaccination, finding that polyclonality and high, but not maximum, antigen receptor avidity correlate with response quality.

This study identifies two distinct CD4+ T cell populations in inflamed lungs, showing that TCF1+ progenitor cells in tertiary lymphoid structures drive Th2 responses in allergic disease.

This study shows that loss of PI3Kδ activity impairs extrathymic Treg differentiation in the colon, leading to autoimmune colitis.

This study shows that Arid2 is essential for follicular B-cell differentiation and antibody responses by regulating transcriptional programs during B cell development.

The paper quantifies frame-specific depletion of TRBV23-1 rearrangements in TCR repertoires and proposes biological explanations for the phenomenon.