Topic · Infectious Diseases · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
5 papers
Yu Zhang, Xinchang Chen, Shiyong Wang…·Jiazhen Chen
A length- and mutation-load-corrected homoplasy screen of 1,813 MDR-TB genomes flags idsA2; its loss raises pretomanid MIC fourfold, delamanid and ethambutol twofold, via isoprenoid flux redirection.
Maximillian G. Marin, Natalia Quinones‐Olvera, Hu Jin…·Maha R Farhat
Complete genomes from 151 clinical M. tuberculosis isolates show gene conversion between paralogs creating diversity hotspots in PE/PPE/ESX genes and T cell antigens, including PPE18.
Alok Kumar Choudhary, Deendayal Patel, William J. Honnen…·Abraham Pinter
Converting human antibody A194-01 from IgG1 to IgM broadens glycan recognition and boosts urinary lipoarabinomannan detection, and RU95-C1, a mannan-targeting antibody, works as a capture partner.
Melissa Dalcina Chengalroyen, Nurudeen Oketade, Aneta H. Worley…·David Michael Lewinsohn
Deleting early riboflavin genes (ribA2 in both species, ribG in M. smegmatis) sharply reduced MAIT cell activation, while ribH deletion raised recognition of M. tuberculosis only.
Annamarie E. Bustion, Jacqueline P. Ernest, Firat Kaya…·Veronique Anne Dartois
Rabbit lesion microdissection and pharmacokinetic modeling show bedaquiline takes months to reach deep caseum and years to clear, while TBAJ-587 and TBAJ-876 shorten these windows.