MicroRNA in disease regulation

This study identifies miR-15b/16-2 as tumor suppressors in T-cell acute lymphoblastic leukemia by showing their role in inhibiting proliferation and promoting apoptosis through repression of BCL-2 and CYCLIN D3.

This study determines the structure of pre-miR-20a and identifies structural features that regulate its Dicer-TRBP processing and maturation efficiency.

This study examines the effects of miR-210 locus deletion on cellular homeostasis in human and mouse cells, revealing deregulation of neighboring genes and unexpected lack of miR-210 target enrichment.

This study identifies miRNAs differentially expressed during RV16 infection and links them to host genes involved in antiviral responses and viral progression.

This study develops MIRROR2, a network-based method to identify sex-specific regulatory mechanisms in cancer by analyzing miRNA and target gene expression across three cancer types.

This study identifies miR-29a-3p as a regulator of metabolic dysfunction and genome stability in Fanconi anemia by modulating the PI3K/AKT and TGF-beta pathways.

This study benchmarks miRNA target prediction algorithms using single-cell co-sequencing data, showing varying performance across species and target numbers.

This study predicts host miRNA binding sites in SARS-CoV-2 and Hepatitis E Virus genomes using RNAhybrid, identifying potential regulatory interactions with strong free energy values.

This study examines how miR-502-3p affects GABA A subunits, synaptic proteins, mitochondrial morphology, and gene expression in hippocampal neurons.

This study identifies miR-193b-3p downregulation via the ERK/EZH2/DNMT1 axis in ovarian cancer metastasis initiating cells, showing its role in promoting cancer stem cell properties and invasion.

This study uses machine learning to predict miRNA expression and identify genetic regulators, revealing miRNA-gene regulatory relationships and pathway-specific associations.

The paper analyzes miRNA-mediated gene regulation during early T cell activation using multi-omics data, revealing distinct regulatory patterns based on translation efficiency and miRNA binding site density.

This study investigates how Candida species influence oral cancer progression through miRNA regulation, showing C. albicans drives oncogenic pathways while C. parapsilosis affects metabolic processes.

This paper reviews the interplay between SOX10 and microRNAs in melanoma, identifying key network motifs and their role in regulating tumor plasticity and therapy resistance.

This study shows that miR-29a-5p reduces astrocyte injury and HT in ischemia-reperfusion models, improving outcomes in acute ischemic stroke.

This study introduces peptide barcodes to measure multiple miRNA activities in parallel, validated by fluorescent reporters, and demonstrates robust profiling across three cell lines.

The paper creates a spatio-temporal miRNA atlas in mice, identifying age-related miR-155-5p increase driven by microglia, independent of sex.

This paper introduces REPRESS, a deep learning model that predicts cell-type-specific microRNA binding and mRNA degradation from RNA sequences, outperforming existing methods in multiple tasks.

This study shows that loss of miR-21 in MYC-driven prostate cancer reduces tumor progression by affecting cell-type-specific gene regulation and immune infiltration.

The paper identifies 1,747 isomiRs and over 5 million microRNA/isomiR-mRNA interactions, finding that isomiRs bind mRNAs differently from their parent microRNAs.

This study identifies let-7 as a regulator of AT2 cell differentiation and fibrosis prevention by controlling oncogenic networks and epigenetic changes.

This study identifies nuclear miRNA:Argonaute complexes and their chromatin-associated RNA targets, showing miRNA-mediated gene silencing occurs in both nucleus and cytoplasm.

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

The paper investigates target-mediated miRNA degradation (TDMD) in Drosophila ovarian cells, showing that Dora, the Drosophila ortholog of ZSWIM8, mediates miRNA degradation and affects Notch signaling.

This study identifies miR-631 as a tumor suppressor in OSCC that targets RAB11A, reduces proliferation, and promotes apoptosis, with potential therapeutic applications.

The paper identifies a miRNA that regulates oxidative stress in myocytes by modulating Wsb1 expression and the NF-κB signaling pathway.

This study identifies miRNA-29 targets and functions in skin repair using miRNA-CLIP and ASO, revealing roles in protein folding, RNA processing, and cell adhesion.

This study evaluates miRNA-based therapy for medulloblastoma using a xenotransplant model, showing reduced tumor growth and invasiveness through miRNA restoration.

The paper introduces miRBench, a benchmark dataset for microRNA binding site prediction that reduces miRNA frequency class bias, showing improved performance with a simple CNN model.

The paper shows that miR-181d degradation via a PNPT1-ATR feed-forward loop increases MGMT expression variance, leading to temozolomide resistance in glioblastoma cells.