Neuroscience and Neuropharmacology Research

The paper identifies sex and experience-dependent regulation of synaptic protein turnover using SILAM in the hippocampus, finding sex-specific changes in ASD risk genes and experience-induced stabilization of PSD proteins.

The paper compares synaptic properties of pyramidal neurons in M2 to those in M1 and PFC, finding M2 synapses exhibit intermediate characteristics between the two.

The paper demonstrates transregional astrocyte-dependent metaplasticity in the hippocampus, showing that SO priming inhibits LTP in DG MML synapses via astrocytic TNF signaling and GluN2B receptor activation.

This study shows that satellite glial cells regulate synaptic plasticity in sympathetic neurons to maintain homeostasis, with disruptions observed in spontaneously hypertensive rats.

The paper identifies specialized axo-spinous contacts between layer 5 cortical terminals and thalamic spines, showing their functional role in synaptic transmission and motor learning.

This study shows that Doc2 and Syt7 knockout mice exhibit increased CA3 burst activity, suggesting their role in regulating network activity rather than neurotransmitter release.

This study shows how presynaptic terminals modulate spontaneous release frequency during early synaptic plasticity using an entropic force framework, revealing changes in synaptic vesicle pool structure and effects of P301L tau.

This study shows that GluD1R current is inhibited by extracellular protons in mouse serotonin neurons and that GluD1R-deficient mice show impaired CO2-induced behavioral responses.

The paper examines region- and layer-specific glutamatergic synapse maturation in the developing cortex, finding that layers involved in higher-order circuits mature later, particularly in layer 1 during adolescence.

This study investigates the role of GluN2D-containing NMDA receptors in dentate granule cells, showing their importance in excitability, synaptic plasticity, and spatial memory.

This study shows that BDNF-TrkB and NMDAR signaling pathways synergistically regulate KCC2 function, trafficking, and degradation through distinct Ca2+-dependent mechanisms.

This study examines sex-dependent astrocytic morphology in the medial habenula and its modulation by metabolic and inflammatory factors.

The paper measures the energy cost of learning-based tasks in mice and finds that post-learning fuel consumption decreases, suggesting energy minimization during learning.

The paper identifies localized mRNAs and proteins in cortical layer 1 synapses, showing specialized transcriptomes and suggesting local translation supports layer-specific functions.

The paper identifies HCN1 channels in GABAergic amygdalar neurons as a key driver of sex-specific aggression, showing that modulating HCN1 affects aggression levels in male and female mice.

The paper maps the expression of three δ2-protocadherin genes in primate basal ganglia, showing complementary patterns that align with functional subdivisions and suggest molecular codes for parallel circuits.

This study uses dynamic mode decomposition to analyze Ca2+ signaling in human astrocytes, showing cholesterol affects Ca2+ dynamics by shifting activity toward oscillatory states or suppressing it.

This study develops a biophysical model of the glutamate-glutamine cycle during ischemia, showing that synaptic failure is due to EAAT dysfunction and sodium gradient collapse, not glutamate release or glutamine synthetase.

The paper uses electron microscopic immunocytochemistry to map the subcellular localization of D1R and D2R in the mouse hippocampus, revealing distinct synaptic and non-synaptic distributions.

The paper identifies a long-range inhibitory mechanism in striatal circuits that links synchronized cholinergic activity to pause generation during reinforcement learning.

The paper identifies ANO3-ITPR1 signaling as a caspase-independent mechanism for synaptic phosphatidylserine exposure, which controls synapse pruning during development and neurodegeneration.

The paper investigates compartment-specific feedback mechanisms in neurons using computational models to show that local calcium signals can encode separate error signals for homeostatic regulation.

This study identifies PRRT1/SynDIG4's role in regulating GluA1 AMPA receptors during LTP by sequestering the GluA1 C-terminus via a lipid modification, thereby affecting CaMKII access and LTP induction.

The paper compares nanoscale organization of GABAergic synapses in somatic and dendritic compartments, finding structural and functional differences that affect inhibitory strength and signaling.

This paper develops an orientation-invariant morphometry framework to analyze dendritic spines and finds they form a continuum rather than distinct subtypes.

This study investigates the role of Munc13 in evoked somatodendritic dopamine release in dopamine neurons, finding it essential for evoked but not spontaneous release.

SynaptoTagMe enables in vivo mapping and modulation of neurotransmission at single-cell resolution in C. elegans by fluorescently labeling and ablating vesicular transporters.

This study identifies Btbd11 as a regulator of glutamatergic synapse organization in GABAergic inhibitory interneurons, showing its role in phase separation and synaptic nanoarchitecture.

The paper uses CRISPR/Cas9 knockout screening in chick embryos to identify GSK3β as a regulator of axon initial segment structural plasticity during development.

This study shows that Hrs, an ESCRT-0 protein, modulates AMPA receptor currents and Ca2+-dependent signaling by sensing and responding to neuronal activity at synapses.