Anwesha Sanyal

This study shows that tau seeding in neurons occurs via transient endolysosomal perforations that remain confined within endolysosomes and require PIKfyve activity.

The paper uses FIB-SEM and ASEM to identify and characterize vesicular ER exit sites in mammalian cells, revealing their abundance and organization.

The paper shows that neurons have constitutive endolysosomal perforations enabling internalized alpha-synuclein fibrils to induce aggregation, and inhibiting PIKfyve kinase reduces this effect.

This study shows that Rab8a and Rab10 deficiencies cause distinct lysosomal and Golgi defects in human neurons, with opposing effects on lysosomal pH and proteostasis of α-synuclein and tau.