Malaria Research and Control

The paper identifies temporal expression patterns of liver-stage malaria antigens and shows that combining antigens with different temporal profiles improves vaccine efficacy.

This study identifies PfCoronin's role in artemisinin resistance by showing mutations impair hemoglobin uptake and modulate drug susceptibility during the ring stage of Plasmodium falciparum.

This study evaluates three long-acting ivermectin formulations in cattle to identify the most effective for malaria vector control, finding Mdc-STM-001 achieves sustained mosquitocidal efficacy for at least two months.

The paper identifies CXCR6⁺ CD127⁻ Tr1 cells as key regulators in Plasmodium falciparum infection, showing they balance immunity and parasite persistence.

This paper identifies AgMOBP1 and PfSyn5 as a critical mosquito-parasite interface for malaria transmission and shows antibodies against PfSyn5 can completely block transmission at low concentrations.

This study develops a self-amplifying RNA vaccine against Plasmodium falciparum malaria that induces high functional antibodies with Fc-mediated activities using a dose-sparing regimen.

This study investigates B cell and antibody responses to PfARMA, finding that IgM and IgG predominantly target the N-terminal IDR1 region, but these responses do not correlate with protection against malaria.

The paper identifies VAR2CSA-specific monoclonal antibodies that synergistically enhance phagocytosis of malaria-infected red blood cells when combined, but none inhibit CSA binding.

This study shows that severe malarial anaemia is linked to increased red blood cell production, iron metabolism, tissue injury, and parasite biomass in bone marrow, with better resolution from bone marrow analysis than peripheral blood.

This study shows PfRKIP is essential for Plasmodium falciparum red blood cell invasion and can be functionally substituted by host RKIP, suggesting a potential target for anti-malarial drugs.

The paper investigates whether reduced PfPSS expression affects resistance of PfATP4 mutant parasites to antimalarials, finding no significant change in drug efficacy.

The paper assesses increased insecticide resistance and kdr mutation frequency in Anopheles gambiae s.l. from Sokoto, Nigeria, showing higher resistance levels and widespread L1014F mutation.

This paper develops a nanoparticle-based junctional vaccine targeting PfCSP and compares its efficacy to the R21 vaccine in reducing malaria liver burden in mice.

This paper quantitatively synthesizes evidence on Anopheles stephensi bionomics and epidemiology in Ethiopia, showing its rapid rise as a dominant malaria vector in urban areas.

This study analyzes genomic diversity of Plasmodium vivax in Vietnam, finding decreasing infection complexity, increasing clonal inbreeding, and stable drug resistance allele frequencies over a 10-year period.

This study shows that deleting OTUD7B in astrocytes reduces cerebral malaria severity by inhibiting microvesicle-induced TRAF3/TRAF6-mediated neuroinflammation.

This paper identifies biomolecules associated with Plasmodium falciparum hemozoin as the key drivers of brain endothelial barrier disruption in cerebral malaria.

This study identifies and characterizes long non-coding RNAs in Plasmodium falciparum across asexual and gametocyte stages using long-read sequencing and single-cell transcriptomics.

The paper models IL-6 response in severe malaria using an ex vivo co-culture system and clinical data, showing that IL-6 is context-dependent and influenced by metabolic and thermal cues.

The paper uses machine learning to impute missing mosquito data and improve malaria incidence predictions in Bolivar State, Venezuela, but finds it ineffective for P. falciparum.

The paper shows RIFINs of Plasmodium falciparum bind LILRB1 in different conformations, triggering inhibitory signaling either in trans or cis to suppress immune responses.

This study uses computational models to analyze how erythrocyte deformability affects merozoite invasion and identifies mechanical markers for drug screening.

This study evaluates a PROTAC molecule to degrade p38 MAPK in mosquitoes, disrupting Plasmodium falciparum development and enhancing immune gene expression, suggesting PROTACs as a novel strategy for malaria transmission control.

This study identifies PfATG18 as a regulator of vacuolar membrane dynamics in malaria parasites, linking V-ATPase assembly to endocytic processes and drug resistance.

This study shows Anopheles stephensi bites mainly in the early evening, reducing the effectiveness of bed nets and suggesting the need for additional control measures.

The paper uses photoaffinity labelling to investigate pantothenamide uptake differences between male and female malaria gametocytes, finding no significant uptake differences but potential subcellular localization variation.

The paper introduces Aster, a statistical framework for accurately classifying antimalarial drug efficacy outcomes by accounting for complexity of infection and genotyping limitations.

This study shows that malaria exposure increases cytotoxic Vδ2+ T cell expansion in human tonsil and spleen organoids, with clonal expansion and activation, while not significantly affecting influenza vaccine responses.

This paper develops a joint Bayesian model to analyze P. vivax parasite density, gametocyte density, and mosquito infectivity, showing gametocyte density has the strongest association with infectivity.

This study uses a stochastic agent-based model to show how Plasmodium falciparum population structure responds to transmission intensity and initial diversity, revealing nonlinear patterns in recombination and haplotype dynamics.