Malaria Research and Control

This paper identifies two genetically distinct Hepatocystis clades in wild primates using low coverage whole genome sequencing and describes candidate hypervariable loci potentially involved in immune evasion and host adaptation.

This study evaluates cethromycin's pharmacokinetics and pharmacodynamics in curing Plasmodium berghei liver stages with a single dose.

This study identifies a non-canonical Arp2/3 complex in Plasmodium essential for DNA segregation during male gametogenesis and transmission to mosquitoes.

This study compares the attractiveness of Anopheles arabiensis and Anopheles quadriannulatus to humans by analyzing their abundance in larval samples and adult catches using different trapping methods.

The paper develops a targeted sequencing panel for Plasmodium falciparum that approximates whole genome sequencing for population genetics analyses.

The paper identifies unconjugated bilirubin as a protective metabolite against malaria by inhibiting parasite proliferation and hemozoin formation.

The paper compares var gene expression in asymptomatic Plasmodium falciparum infections and clinical malaria cases during dry and wet seasons in Mali, finding fewer and lower-level var transcripts in asymptomatic carriers.

This study infects pregnant mice with Plasmodium berghei at different gestational stages to investigate how placental malaria affects perinatal outcomes and identifies immune and hormonal changes associated with adverse effects.

The paper identifies DNA sequence cis determinants that drive heterochromatin nucleation and maintenance in Plasmodium falciparum using genetic screening and chromatin immunoprecipitation.

This study identifies structural variants in Anopheles stephensi that contribute to its adaptive success in invasive environments.

This study expresses, purifies, and characterizes the Plasmodium falciparum mPPase, identifying three compounds with micromolar IC50 activity against it.

The paper introduces a statistical framework to estimate haplotype frequencies, multiplicity of infection, and linkage disequilibrium from multi-allelic markers, validated on malaria data from Cameroon.

This study shows that RAS vaccination generates long-lived liver-resident memory T cells specific for abundant sporozoite antigens, which mediate protection but may limit vaccine efficacy against diverse parasite strains.

This study shows that sublethal insecticide exposure during larval development affects adult mosquito blood-feeding behavior and egg-laying patterns, with implications for disease transmission.

This study identifies PfPPM2 as a signaling pathway regulator that controls asexual division and sexual conversion in Plasmodium falciparum by modulating HP1 and histone H3 phosphorylation.

The paper identifies multiple redundant carboxylic acid transporters in Plasmodium falciparum that support mitochondrial metabolism, revealing metabolic flexibility in the parasite.

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

This paper generates a transgenic P. cynomolgi parasite expressing P. vivax CSP to study anti-CSP interventions against relapsing malaria.

This paper reviews GWAS on malaria in Sub-Saharan Africa, finding 99 relevant studies mostly from Kenya and Gambia, with a focus on genetic variants linked to malaria susceptibility, resistance, and severity.

This study reveals that Plasmodium falciparum parasites can express multiple var genes or suppress var gene expression, enabling them to evade host immunity and persist in chronic infections.

The paper surveys larval breeding sites of malaria vectors in Zanzibar City and finds they prefer concrete, semipermanent water bodies with high dissolved oxygen, not yet using polluted sites.

This study shows that surface remodelling in Plasmodium falciparum gametocytes helps evade immune detection and facilitates transmission by controlling their sequestration and release into the bloodstream.

This study examines humoral and cellular immunity to genetically attenuated malaria parasites in humans and identifies key liver-stage antigens for vaccine development.

The paper analyzes RNA methylation and alternative splicing in Plasmodium falciparum and P. vivax clinical isolates using Nanopore sequencing to reveal transcriptome diversity and regulatory mechanisms.

This study uses a CRISPR homing screen to identify essential genes for malaria transmission in mosquito stages, finding a chloroquine resistance transporter-like protein critical for oocyst development.

This study compares gametocyte production and transmission fitness of ART-sensitive and ART-resistant P. falciparum isolates across multiple mosquito species.

The paper analyzes the evolution and prevalence of dhfr and dhps resistance alleles and haplotypes across Africa using whole genome data from multiple countries.

The paper compares thermal suitability models for malaria transmission using constant and fluctuating temperatures, finding that constant temperature models better predict thermal limits than rate summation.

This study shows that Plasmodium falciparum undergoes a rapid metamorphosis after invading erythrocytes, mediated by PV6, which aids parasite survival by altering erythrocyte surface area.

This study identifies two IFN-I-driven hepatocyte antimicrobial programs that control liver-stage malaria by inducing GBPs and lysosomal defense mechanisms.