HIV Research and Treatment

This study investigates how THC affects HIV-infected CD4 T cells using single-cell multiomic analysis, finding no effect on HIV reactivation but altered gene expression and chromatin accessibility.

This study investigates how Lenacapavir disrupts HIV-1 assembly and maturation, revealing a 'premature' lattice formation that prevents infectious virus production.

The paper develops HIV-seq to capture HIV transcripts for scRNA-seq, revealing distinct transcriptional features of HIV-transcribing cells in viremic and ART-suppressed HIV patients.

This study shows that HIV-1 silencing in polyclonal cell populations arises from clone-specific behaviors, not uniform repression, with many clones maintaining stable bimodal expression over time.

The paper identifies a Ca2+-phosphate bridge that stabilizes protein complexes during HIV assembly through phospho-proteomics and structural analyses.

This paper uses humanized mice to study how HIV resistance to broadly neutralizing antibodies (bNAbs) affects the efficacy of AAV-delivered immunotherapy, finding that escape mutation fitness costs and resistance benefits determine therapeutic success.

This study characterizes HIV reservoir clones and shows they can be culled by sustained CTL pressure, with some displaying intrinsic resistance linked to low oxidative stress.

This study identifies GFI1 as a key regulator of HIV latency in hematopoietic progenitors through transcriptomic analysis and functional assays.

This study uses a barcoded SIV infection model to analyze the dissemination bottleneck in rhesus macaques, finding anatomical heterogeneity contributes most to early viral spread variability.

The paper identifies 289 differentially expressed genes in HIV-1 R77Q-infected cells compared to wild-type, revealing an apoptotic signature and failure to upregulate anti-apoptotic genes like bcl-2.

This study shows that targeting CDK12/CYCLIN K induces HIV gene activation and latency reversal through P-TEFb-mediated mechanisms.

The paper develops a fluorescence microscopy method to track HIV-1 DNA in vivo, revealing active and silent viral genomes in humanized mice tissues.

This study finds that comorbid HIV and cocaine use are associated with accelerated brain aging and increased cognitive impairment, with the greatest effects seen in individuals with both conditions.

This study investigates how HIV-1 integration sites influence viral latency and clonal expansion in human memory CD4+ T cells engrafted into mice.

This study shows that inhibiting glycolysis in TB-infected macrophages reduces HIV-1 spread by blocking tunneling nanotubes and Siglec-1 expression.

The paper identifies HIV-producing resting T cells as the primary source of virus production in lymphoid tissue germinal centers before ART and shows their role in PANoptosis and persistence during treatment.

DNA origami particles displaying eOD-GT8 with a synthetic T helper epitope gave antigen-focused germinal centers and expanded VRC01-class precursors in humanized mice after one immunization.

The paper shows HIV causes collagen deposition in lymphoid tissue early in infection, linked to TGF-β+ macrophages and HIV RNA-producing cells, suggesting early ART may not prevent fibrosis.

This study identifies ZL0580 as a BRD4-targeting small molecule that suppresses HIV in vivo through epigenetic mechanisms, showing potent antiviral effects in a humanized mouse model.

This study examines how the duration of initial HIV-1 viremia affects the functional properties of HIV-specific T cell receptors in individuals with HLA-B*58:01.

This study shows that IL-6 restricts pre-thymic T cell lineage commitment in SIV-infected rhesus macaques, contributing to loss of viral control.

The paper identifies shared maturation pathways of V3-glycan broadly neutralizing antibody lineages in humans and rhesus macaques, revealing convergent mutations and evolution patterns.

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

This study develops an immune organoid model to study HIV infection, treatment, rebound, and intervention in human lymphoid tissues.

This study shows that soluble HIV-1 Vpu forms an equimolar complex with Ca2+-calmodulin, causing conformational changes and dissociation of Vpu oligomers.

This study investigates the B-cell response to transient HIV viraemia in elite controllers, revealing TLM heterogeneity and the role of innate-like B cells.

This study shows that heterologous boosting enhances MPER-specific B cell responses in MPER/liposome vaccines by increasing B cell affinity and reducing competition from helper peptides.