Sperm and Testicular Function

The paper shows that mTas1r3+ cells are critical for sperm development and male fertility in mice, as their deletion causes infertility.

The paper analyzes vertebrate sperm protamine sequences to identify conserved residues and proposes dityrosine or cysteine-tyrosine cross-linking as mechanisms for protamine structure in metatherians.

This study identifies MFN2's role in spermatogenesis by interacting with Nuage proteins and translational machinery to regulate gamete-specific mRNA fates and male fertility.

This study shows that KIF9 is essential for male fertility by regulating flagellar waveforms in ciliated cells, as KIF9 knockout males are sterile despite normal sperm motility.

The paper characterizes the porcine sperm microbiome using RNA-seq, identifying bacterial phyla, potential pathogens, and antibiotic resistance genes associated with semen quality traits.

This study shows HIPK4 is essential for spermiogenesis and male fertility in mice, with defects in sperm head morphology and fertility.

The paper investigates the non-apoptotic role of cleaved caspase-3 in rat male germ cell development, showing its involvement in cell cycle regulation and quiescence.

This study identifies MGAT4D as a protective factor for male germ cells against mild heat stress, showing that its absence increases sensitivity to heat.

This study develops an automated platform to screen compounds against human sperm motility and acrosome reaction, identifying new contraceptive candidates from a large molecular library.

This study identifies NHR-23/NR1F1 as a critical regulator of spermatogenesis in C. elegans, functioning downstream of the sex determination pathway and independent of the SPE-44 network.

This study identifies distinct epigenetic programming in regenerative spermatogonial stem cells and progenitors in mouse testis using integrative epigenomic analysis.

This study identifies SYCP2 translocation and frameshift variants as causes of male infertility through genetic analysis and functional modeling in yeast.

The paper identifies genoinformative markers (GIMs) in mammalian spermatogenesis showing allelic expression bias, suggesting selective sweeps and evolutionary conflict between germline and somatic functions.

This paper shows that Fbxo7 is required for male fertility in mice, as its deficiency leads to sterile males with abnormal spermatid disposal during spermiogenesis.

The paper identifies 100+ genes associated with NOA and spermatogenesis through transcriptomics and shortlists 20 RNA molecules for diagnostic applications.

This study shows that cyclin B3 is not required for male meiosis despite its meiosis-specific expression, as male mice lacking cyclin B3 are fertile with normal spermatogenesis.

The paper examines changes in histone modifications in male germ line cells of young and aged mice, finding age-related differences in modification intensities, particularly on sex chromosomes.

The paper maps gene expression changes during meiotic prophase-I in mice spermatogenesis, identifying key transitions and gene regulation patterns.

This study shows androgen promotes differentiation of PLZF+ spermatogonia via an indirect regulatory pathway involving Sertoli cells and multiple intermediate molecules.

This study proposes that male infertility may result from stochastic transmission of cytoplasmically-inherited proteins during spermatogenesis, using a simple stochastic model to demonstrate reduced viable sperm proportion under certain parameters.

The paper analyzes single-cell sperm RNA-seq data from fathers of autistic and healthy children to identify mutation clusters and expression differences associated with ASD risk.

The paper shows BRG1 interacts with SCML2 to regulate transcription during spermatogenesis, highlighting a novel SWI/SNF-PRC1 co-operation mechanism.

This study characterizes the porcine sperm transcriptome through RNA-seq, identifying seasonal changes in gene and microRNA expression related to oxidative stress and DNA damage.

The paper identifies a splice donor variant in CCDC189 associated with asthenospermia in Nordic Red cattle and integrates findings into the OMIA database.

This study examines the small RNA profile of house sparrow sperm to explore how paternal age affects offspring fitness, finding no significant differences in miRNA and tRNA fragments between aged and prime sperm.

This study uses single-cell RNA sequencing to analyze transcriptional changes in spermatogonia and spermatocytes across developmental stages, revealing age-related gene expression differences and pathway utilization.

The paper creates a single-cell transcriptomic atlas of mouse spermatogenesis, identifying key developmental stages and X chromosome transcriptional dynamics.

The paper shows that ring canals in Drosophila testes allow cytoplasm sharing during spermatogenesis, independent of fusomes.

The paper examines Sox2 expression dynamics in rat germ cells during development, showing changes in localization from cytoplasm to nucleus during spermatogonia emergence.

This paper systematically reviews and assesses the clinical validity of genes linked to human male infertility, identifying 67 confidently linked genes across 81 phenotypes.