Mesenchymal stem cell research

The paper shows that MSCs reduce dysfunction in KOA synovial fluid-modulated monocytes via IL-6 and CCL2, restoring phagocytosis and reducing inflammation.

The paper uses time-lapse imaging to analyze lineage topology and replication kinetics in human BMSC colonies, revealing synchronized cell cycles and regulatory factors linking non-dividing cells with proliferating cells.

This study shows that estrogen-mimetic compounds in cell culture media affect human mesenchymal stromal cells differently in males and females.

This study shows that PPAR beta delta activation in hBM-MSCs enhances their cytoprotective effects via ANGPTL4 in a pre-clinical ALI model.

This study shows freshly isolated MSCs can differentiate into macrophage-like and fibrocyte-like cells, revealing new insights into MSC plasticity and immune regulation.

This study uses single-cell RNA sequencing to analyze cell therapy samples in osteoarthritis, identifying tissue-specific pathways and treatment correlations while highlighting challenges in patient heterogeneity.

This study shows that stromal cells with lineage-specific gene programs are more prone to adopt opposing phenotypes, supporting coordinated trans-differentiation between osteoblasts and adipocytes.

This study shows that taurine transporter SLC6A6 promotes mesenchymal stromal cell function by supporting osteogenic differentiation and hematopoietic stem cell maintenance.

This study identifies differences in the secretome of neonatal mesenchymal stem cells from mothers with obesity compared to normal-weight mothers, showing altered redox capacity and adipogenic signaling.

This study engineers glycogen metabolism in mesenchymal stem cells to improve their survival during starvation and therapeutic efficacy in pulmonary fibrosis.

This paper develops a device-encapsulated MSC system for sustained secretome delivery to treat ischaemic heart injury, showing improved cardiac function and reduced remodelling in rats.

This paper establishes and characterizes an ovine mesenchymal stromal cell line from peripheral blood, confirming its mesenchymal origin and susceptibility to various viruses.

This study identifies Nestin+ perivascular cells as contributors to endometrial epithelial regeneration through estrogen-stimulated suppression of Notch signaling.

This paper develops an in vitro assay to measure Deramiocel's anti-fibrotic activity, showing it suppresses collagen expression and correlates with clinical benefits in DMD patients.

This study shows that age-related decline in canine lung mesenchymal stromal cell proliferation is linked to quiescence rather than senescence, with minimal transcriptomic changes.

The paper identifies an in vitro assay to predict the ageing-reversal potency of stem cell-derived extracellular vesicles in a rat model of premature cardiac senescence.

This study examines how different culture conditions affect the functional properties of adipose-derived stromal cell secretomes in angiogenesis, collagen deposition, and immunomodulation.

This study shows that human dental pulp stem cells can be differentiated into neuron-like cells with electrophysiological activity, highlighting the importance of serum-free culture protocols.

This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.

This paper introduces a genetic priming method using IRF1 to sustainably enhance MSC potency and suppress immunogenicity compared to biochemical priming.

This study investigates how glucose and fructose, along with oxygen levels, affect stem cell growth, cytokine production, and differentiation in multicellular organisms.

The paper screens MSC morphology in response to inflammatory priming to identify optimal conditions for EV production and microglia modulation in bioreactors.

The paper shows that short heat shock alters mesenchymal stem cells' transcriptome, leading to long-term activation of lineage commitment genes.

This study shows IFT20 regulates mesenchymal stem cell fate by controlling TGF-β-Smad2/3-Glut1 signaling and glucose metabolism, preventing adipocyte differentiation.

This study examines the effect of platelet-rich plasma on adipose-derived mesenchymal stem cells differentiation into cardiomyocytes, finding significant improvements in GATA-4 and cTnT expression compared to controls.

The paper identifies MSC subpopulations and their differential responses to inductions using single-cell RNA-seq, revealing subtype-specific gene expression and differentiation potential.

This study shows that primed endothelial colony forming cells improve brain outcomes in growth restricted newborn piglets by repairing vasculature and reducing inflammation.