Cardiac electrophysiology and arrhythmias

A Halbach array modulates excitation wave speed in human cardiac cell assemblies with magnetic nanoparticles, increasing conduction velocity by up to 25% when aligned with the wave direction.

This study uses optogenetics to measure cardiac parameters in mouse hearts, revealing that reduced inward rectifying K+ currents and disrupted coupling increase arrhythmia risk.

This study extends SANC models with β-AR signaling to show that sympathetic stimulation can compensate for hypocalcaemia-induced bradycardia in human and rabbit cells.

This study introduces and validates an adaptive QTc formula (QTcAd) that adjusts for age demographics, showing improved performance across human and guinea pig age groups compared to existing formulas.

This study shows 14-3-3 promotes CaV1.2 sarcolemmal expression and nucleates its super-clustering in response to isoproterenol in cardiomyocytes.

This study uses a rabbit atrioventricular node model with autonomic nervous system control to simulate AVNRT onset, sustainability, and termination, revealing how ANS modulation affects these processes.

This paper develops sex-specific cardiac emulators to predict drug-induced QT interval prolongation in real-time, achieving high accuracy and drastically reducing computational time for drug safety assessments.

This study shows that the R14del mutation in phospholamban increases pentamer stability, reducing its ability to regulate SERCA and impairing cardiac calcium handling during physiological stress.

This study compares the effects of obesity and diabetes on action potential parameters and ion currents in rat ventricular myocytes, finding distinct impacts of obesity alone versus obesity with diabetes.

The paper develops a polygenic risk score for baseline QTc and shows it predicts sotalol-induced QT prolongation in a cohort of healthy subjects.

This paper investigates how empagliflozin affects late sodium currents in specific LQT3 mutations, finding it selectively inhibits these currents in some mutations but not others.

The paper investigates deriving action potential biomarkers from a linearised action potential function.

This study identifies direct interactions between PKA catalytic subunit and C-terminal domains of cardiac CaV1.2 channels, revealing their role in modulating β-adrenergic regulation.

This study describes the first natural history of Timothy syndrome, identifying common extra-cardiac features beyond cardiac issues.

The paper develops a data science pipeline to analyze interactions between Ca2+-regulating proteins and cardiovascular diseases, identifying associations with oxidative stress and cardiac arrhythmias.

The paper uses in-silico trials to evaluate the efficacy of SK and K2P channel block in atrial fibrillation, finding that combined block significantly improves cardioversion success.

This study examines the structure-function relationship of Ryanodine Receptor (RyR) clusters in sinoatrial node cells, showing how heterogeneities in cluster size and location influence calcium release and action potential firing rates.

This study introduces AB2, a photochromic ligand that modulates cardiac electrophysiology via light, converting ventricular arrhythmias into sinus rhythm in an ex-vivo heart model.

CardioMEA is a data-analysis platform for HD-MEA data from iPSC-CMs, enabling electrophysiological analysis of cardiac diseases and drug responses.

This study analyzes age-dependent gene expression and electrophysiological changes in pediatric patients with congenital heart disease using computational modeling.

This study identifies multiple beta cell-independent mechanisms causing hypoglycemia in Timothy syndrome using a novel mouse model.

The paper identifies a rare non-coding enhancer variant in SCN5A associated with Brugada syndrome in Thailand, showing it disrupts a transcription factor binding site and reduces sodium current.

This paper identifies the fully activated open state of KCNQ1 as critical for β-adrenergic stimulation of IKs channels, showing that modulators enhancing this state can restore function in LQT1 mutants.

The paper investigates the combined effects of SCN5A enhancer variants on gene expression and demonstrates their additive regulatory impact in vitro and in vivo.

This study shows that calcium transients dampen action potential alternans, and their absence leads to more unstable alternans.

This study evaluates the inhibition of hERG channels by verapamil using CiPA protocols, finding similar IC50 and Hill coefficient values across labs and demonstrating improved success rates with a revised protocol.

This study uses computational models to show female atrial cardiomyocytes in AF have higher Ca2+-driven arrhythmia risk than males, with specific interventions identified to address these differences.

This paper evaluates how functional variant data and penetrance estimates improve risk stratification for LQTS in KCNH2 missense variant carriers.

The paper introduces Ithildin, an open-source library for simulating excitable media, demonstrating its use in cardiac electrophysiology simulations.

The paper uses human-based modeling to evaluate cell therapy in acute and chronic myocardial infarction, finding that cell heterogeneity and Purkinje system function influence arrhythmia risk.