Topic · Pulmonary and Respiratory Medicine · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
68 papers
Gabriel Gallo-Oller, Guillem Pons, Júlia Sansa-Girona…·Josep M Roma
This study shows TRIB3 silencing reduces Akt pathway activity and PAX3-FOXO1 levels in high-risk rhabdomyosarcoma, leading to decreased tumor growth and improved survival.
Justin W. Magrath, Ilon N. Goldberg, Danh D. Truong…·Sean Bong Lee
The paper shows enzalutamide reduces DSRCT growth independently of AR, challenging the hypothesis that AR drives male predominance in this cancer.
Peter G. Hendrickson, Kristianne Michelle Oristian, MaKenna R. Browne…·David G. Kirsch
This study generates genetically engineered mouse models of CIC-DUX4 sarcoma that spontaneously develop tumors and express the fusion protein, validating CIC-DUX4 as a transcriptional activator.
Eleanor M. O’Brien, Carmen Tse, Ian Tracy…·Zoë S. Walters
This study shows that combining EZH2 inhibition with retinoic acid treatment reduces RMS cell proliferation by inducing apoptosis or differentiation depending on the RMS subtype.
Martin F. Orth, Didier Surdez, Tobias Faehling…·Thomas G. P. Grünewald
The paper presents a multi-omics cell line atlas for Ewing sarcoma, identifying new target genes and regulatory mechanisms of EWSR1-ETS fusion oncogenes.
Riaz Gillani, Sabrina Yvonne Camp, Seunghun Han…·Eliezer M. Van Allen
This study identifies inherited pathogenic variants in DNA damage repair genes as a distinct germline risk factor for Ewing sarcoma, with FANCC showing significant enrichment.
Christopher E. Lietz, Erik T. Newman, Andrew D. Kelly…·Dimitrios Spentzos
This study identifies DNA methylation subtypes in osteosarcoma that predict clinical outcomes and response to chemotherapy.
Christopher B. Lietz, Cassandra C. Garbutt, William Thomas Barry…·Dimitrios Spentzos
The paper identifies microRNA-mRNA networks associated with prognosis in osteosarcoma and validates their predictive value across independent datasets.