Helicobacter pylori-related gastroenterology studies

The paper re-analyses public multi-omics data to characterize the gastric mucosal immune and metabolic landscape of H. pylori infection and identifies CagW as a promising mRNA-LNP vaccine antigen.

This study shows that Lgt is essential for membrane and flagellar integrity in H. pylori, and that revertant cells can overcome this stress through gene expression changes.

The paper shows that gastrin loss activates a vagal reflex that promotes CCK2R+ stem cell expansion and preneoplasia in gastric inflammation.

This study investigates the fitness benefits and costs of the H. pylori Cag-T4SS and CagA during stomach infection, showing initial benefits and later costs due to inflammation.

This study evaluates the diagnostic performance of fluorescence-based rapid on-site evaluation (F-ROSE) for H. pylori antimicrobial susceptibility testing before and after algorithm optimization, showing improved sensitivity and accuracy.

This study shows that diet-induced obesity worsens pre-cancerous changes in mice infected with Helicobacter pylori, particularly in those with genetic predispositions to gastric disease.

This paper introduces a culture-free rapid phenotypic antimicrobial susceptibility test for H. pylori using fluorescence ROSE technology, achieving 84.6-84.6% concordance with culture-based methods and reducing turnaround time to 1 hour.

This study investigates the role of RsfS in H. pylori, showing it is required for low-growth states and chronic infection.

This study develops a gastric microbial model community to investigate H. pylori interactions with other microbes and their impact on pathogenesis.

This study identifies allelic variation in H. pylori cell surface genes that influence exoproteome binding and gastric tissue adherence through structural changes in lipopolysaccharide.

This study models how dynamic gastric pH affects H. pylori eradication and antibiotic resistance by incorporating pH as a state variable in an in-host model.

This paper investigates the morphological transformation of Helicobacter pylori from helical to coccoid form using microscopy techniques, revealing it occurs without a U-shaped intermediate and involves peptidoglycan thinning and membrane bulging.

This study identifies CEBPB as a key transcription factor linking H. pylori infection to gastric cancer progression through immune evasion and genomic instability.

This study shows that H. pylori-induced gastric metaplasia enables F. animalis colonization, which is associated with increased Gal-GalNAc and reduced acidity.

This study validates a modified Gram stain technique to identify mucosal tissue with high bacterial biomass for downstream microbiota analysis, improving reproducibility and reducing noise in sequencing studies.

This study shows that autoimmunity and H. pylori infection together promote gastric tumorigenesis and immune suppression in mice.

This study characterizes HERV expression in gastric cancer tissues and finds differential expression in tumor samples, particularly those with H. pylori infection.

This study shows that infecting mice with Helicobacter pylori at a young age leads to larger gastric organoids and alters cell type composition compared to adult infection.

The paper analyzes ICE content and variability in 1011 H. pylori strains, showing their prevalence, gene erosion, and role in shaping genome architecture through horizontal transfer and recombination.

The paper introduces HPgnomAD, a global H. pylori genome database revealing evolutionary patterns and clinical implications in East Asia.

This study uses machine learning to improve metronidazole resistance prediction in Helicobacter pylori using whole-genome sequencing, achieving better accuracy than traditional methods.

The paper analyzes cagY sequences from Helicobacter pylori strains to identify ancestry and disease associations, finding specific motifs and structural changes linked to gastric cancer.

This study identifies Muc6-expressing isthmus progenitors as key contributors to gastric regeneration and metaplasia through myeloid-mesenchymal interactions.

This study shows androgens suppress Helicobacter-induced gastric inflammation by modulating ILC2 activation, with androgen depletion worsening inflammation and accelerating preneoplastic lesion development.

This study characterizes the genomic and functional diversity of Helicobacter pylori plasmids, identifying two major groups with distinct roles in pathogenicity and horizontal gene transfer.

This study uses Mendelian randomization to find causal links between H. pylori antibodies and five skin disorders, identifying positive associations with alopecia areata and pruritus.

The paper analyzes virulence and antibiotic resistance genes in Helicobacter pylori and other campylobacteria, finding H. pylori has the highest number of virulence genes and unique patterns of resistance.

This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.

The paper analyzes H. pylori genomes to identify subpopulations in Colombia and finds selective pressure on membrane proteins drives adaptation to local populations.