Circadian rhythm and melatonin

The paper identifies a new subtype of pineal projection neurons in zebrafish that express melanopsin and share developmental features with classical projection neurons.

This study demonstrates that melanopsin-expressing ganglion cells in fetal mouse retinas are light-responsive and identify the transduction pathways involved.

This study shows CNOT1 enhances phosphorylation of CLOCK and BMAL1 via PKA, stabilizing them and inhibiting their transcriptional activity in the mammalian circadian clock.

This study shows that light-evoked attraction/avoidance behaviors in mosquitoes are circadian and vary between day- and night-biting species.

This study identifies circadian-regulated miRNA-mRNA interactions in Drosophila using CLEAR-CLIP, revealing functional roles of specific miRNAs in circadian control.

The paper shows XBP1s regulates 12h-transcriptome rhythms in liver, aligning with central dogma information flow, and identifies GABP as a novel regulator.

This study identifies hnRNP K as a transcriptional amplifier of DBP, regulating circadian rhythms through chromatin accessibility and mRNA stabilization in Drosophila.

This study identifies PSI as a regulator of circadian period in Drosophila by modulating thermosensitive alternative splicing of timeless.

PREMONition predicts circadian clock-regulated molecular networks by integrating functional relationships across species, validated in yeast with gene expression and light sensitivity data.

The paper investigates the synaptic circuits in intrinsically photosensitive retinal ganglion cells (ipRGCs) that encode light intensity, showing that Type 6 ON cone bipolar cells provide the strongest luminance signal.

This study identifies 351 new genetic loci associated with chronotype using data from 697,828 individuals and links them to circadian biology and disease.

The paper identifies novel genes and reveals molecular diversity in mouse intrinsically photosensitive retinal ganglion cells (ipRGCs), showing unexpected complexity in their gene expression patterns.

This study identifies miR-263b as a regulator of circadian rhythms in Drosophila by inhibiting Beadex expression, affecting structural plasticity of sLNv neurons.

This study identifies PtbHLH1a, a bHLH-PAS protein in Phaeodactylum tricornutum, that regulates light-dependent diurnal rhythms, cell cycle, and gene expression, with conserved homologs across diatom species.

The paper extends a framework for quantifying growth and proteome composition to circadian metabolism in cyanobacteria, showing that storing carbon and nitrogen leads to an optimal growth strategy constrained by slow proteome relaxation.

The paper identifies a multiscale temporal regulatory network involving genes that regulate circadian, cell cycle, and aging processes, enriched for signal transduction, metabolism, and stress response genes.

The paper identifies rhythmic gene expression across human tissues using computational methods and highlights implications for circadian medicine in cardiovascular disease.

This study shows that HDAC3 restricts long-term memory and synaptic plasticity in aging hippocampus by repressing Per1, a circadian gene, without affecting circadian rhythms.

This study investigates how circadian clock neurons in the suprachiasmatic nucleus (SCN) respond to light and mediate time-of-day dependent rhythms in behavior.

This study shows that blue light modulates alpha rhythm in the occipital cortex of totally blind individuals with non-visual light perception, suggesting ipRGCs influence brain activity beyond vision.

This study identifies a circuit in Drosophila where DN1p neurons integrate circadian, homeostatic, and environmental cues to regulate sleep onset.

The paper curates and integrates circadian clock time series data from Drosophila melanogaster to analyze variability in core clock proteins, revealing unexpected differences in peak time variance between PERIOD and TIMELESS.

The paper addresses the issue of dependent p-values in rhythm detection methods for genome-wide expression time series and proposes corrections for accurate statistical significance estimation.