Erik D. Herzog

This study shows that viral replication byproducts called cbVGs drive changes in circadian gene expression during infection through distinct immune pathways, with ARNTL2 playing a key role in amplifying antiviral responses.

This study shows that fetoplacental circadian rhythms develop in utero and synchronize with the mother, with maternal glucocorticoids playing a key role in this synchronization.

This study develops programmable gene circuits that deliver IL-1Ra in a circadian manner to protect cells from inflammation.

This paper develops a dual-responsive synthetic gene circuit that combines circadian and inflammatory signals to enable timed and enhanced therapeutic drug delivery in inflammatory arthritis.

This study shows that daily glucocorticoids influence glioblastoma growth and circadian synchronization with the host, with effects dependent on timing and clock genes.

The paper develops MITE to infer functional connectivity in the SCN and finds a conserved, sparse connectome with hubs that drive circadian synchrony.

This study shows that TMZ efficacy in glioblastoma varies with time-of-day due to circadian rhythms in MGMT expression and promoter methylation, with optimal treatment at the peak of Bmal1 expression.

The paper investigates the role of Kv12-encoded K+ channels in regulating day-night firing rate rhythms in SCN neurons, finding they drive the nighttime decrease in firing rates.

This study shows fetal circadian rhythms develop early in pregnancy and synchronize with the maternal rhythm, influenced by maternal glucocorticoids.

This study ablates VIP neurons in the adult SCN of mice and finds dampened glucocorticoid rhythms but preserved circadian locomotor behavior, suggesting distinct roles for VIP neurons in development and adulthood.

The paper develops nTracer, an ImageJ plugin for reconstructing neuronal morphology in densely labeled mouse brains using multispectral tracing.

This study identifies how VIP SCN neurons use firing rates and neuropeptide release to entrain circadian rhythms in gene expression and behavior.

This study investigates how circadian clock neurons in the suprachiasmatic nucleus (SCN) respond to light and mediate time-of-day dependent rhythms in behavior.