Circadian rhythm and melatonin

This study shows HNF4A trans-represses CLOCK:BMAL1 and is a core component of tissue-specific circadian networks in liver and colon cells.

This study measures pupil responses to melanopsin-directed contrast pulses and finds they are reliable and insensitive to background radiance changes.

LimoRhyde provides a flexible framework for analyzing rhythmic transcriptome data, enabling detection of differential rhythmicity and expression in circadian systems.

This study identifies MDM2 as a regulator of PER2 degradation and shows it influences circadian rhythm period length through a phosphorylation-independent mechanism.

This study shows how the circadian clock and environmental cycles influence cell size control and division timing in cyanobacteria.

The paper identifies robust circadian rhythms in human skin at the population level and develops single-sample biomarkers for circadian phase.

The paper performs a bifurcation analysis of a mammalian circadian clock model to understand how gene expression and protein activity influence oscillatory dynamics and feedback loops.

This study shows that LPS induces Stat3 mRNA expression in the SCN with daytime peaks and that night-time LPS injection delays locomotor activity recovery in rats.

This paper identifies a circadian output circuit in Drosophila that regulates sleep-wake arousal threshold by connecting circadian neurons to homeostatic sleep centers.

This study shows that foraging time in honey bees affects the molecular clock, with phase differences in clock genes and stronger effects when food is scented with linalool.

This study shows that dKDM2 is not essential for Drosophila viability but regulates circadian rhythms, with loss-of-function mutants showing arrhythmic behavior and overexpression causing shorter periods.

The paper analyzes mouse genome data to show ultradian genes are more evolutionarily conserved and linked to dawn/dusk transitions.

This study identifies genetic loci associated with circadian rhythmicity using UK Biobank data and finds polygenic associations with mood instability and major depressive disorder.

The paper improves rhythm detection in sparsely sampled genome-wide expression time series using bootstrapping and empirical Bayes methods, showing better consistency than existing methods.

The paper shows Drosophila S2 cells exhibit daily gene and metabolic oscillations without canonical circadian regulators.

This study identifies how VIP SCN neurons use firing rates and neuropeptide release to entrain circadian rhythms in gene expression and behavior.

The paper identifies tissue-specific circadian feedback loops by fitting mathematical models to gene expression data from different mammalian tissues.

This study shows that melanopsin-mediated pupil responses are impaired in early-stage Parkinson's disease, suggesting a potential biomarker for disease detection and monitoring.

The paper examines single-cell circadian rhythms in Arabidopsis seedlings, revealing robust oscillations and spatial waves of gene expression that coordinate clock activity across the plant.

The paper investigates how circadian gene expression is regulated across tissues by analyzing transcription factor activity rhythms and chromatin interactions in mouse tissues.

This study shows BMAL1 regulates astrocyte activation and function through cell-autonomous and non-cell-autonomous mechanisms, impacting neuronal survival and brain health.

The paper identifies novel circadian transcripts in the zebrafish retina and distinguishes between light-entrained and free-running oscillations.

The paper shows natural light changes affect circadian gene expression in cyanobacteria through RNA polymerase recruitment controlled by transcription factors.

This study shows that SIK3 regulates circadian rhythms in mice by destabilizing PER2 protein through phosphorylation.

The paper identifies a thalamic nucleus that mediates habenula responses to changes in illumination using calcium imaging and optogenetics in zebrafish.

This study identifies a major QTL on chromosome 2 associated with circadian light sensitivity in Drosophila and finds that the timeless s/ls polymorphism contributes to phenotypic variation.

The paper investigates how translation efficiency contributes to tissue-specific rhythmic and constitutive gene expression in kidney and liver, revealing translational control mechanisms and compensation effects.

This study shows blue light masks circadian behavior in larval zebrafish via a thalamo-habenula pathway, while red light does not.

The paper identifies circadian regulation of snoRNA and their coordination with rRNA maturation in nuclear RNA sequencing data.

The paper develops a mathematical model to predict how circadian rhythms and sleep behavior influence daily pain sensitivity variations.