Hydrogels: synthesis, properties, applications

This paper introduces DNA-based hydrogel microparticles with tunable mechanical properties for 3D cellular systems, showing they can be remodeled by fibroblast spheroids based on their stiffness.

This study systematically evaluates how different photoinitiators affect the physicochemical and biological properties of GelMA hydrogels, identifying optimal conditions for various biomedical applications.

This paper quantifies the rheological behavior of granular hydrogels using the Kamani-Donley-Rogers model with Brittility, showing they behave as brittle yield stress fluids with complex transient properties.

This study demonstrates the use of GelMA hydrogels for 3D cell culture with in situ genetic manipulation and spatially controlled gene expression.

This paper demonstrates a method to release probiotics from hydrogels using mechanical fracture, enabling sustained and controllable release of metabolically active microbes.

This paper introduces a light-sensitive hyaluronic acid hydrogel for 3D cell culturing, differentiation, and harvesting of mesenchymal stromal cells, showing it can modulate cell behavior through light exposure.

This study shows that hydrogel-embedded precision-cut lung slices can maintain premalignant lung lesions for six weeks and respond to a cancer prevention agent.

This study develops a tunable hydrogel combining caprine-derived dECM and DAS for tissue engineering, showing improved mechanical properties and hemocompatibility.

This paper develops liquid-core soft compartments with tunable microporosity to enhance cell migration for tissue engineering.

This paper develops a hydrogel platform for subcutaneous delivery of trastuzumab, achieving sustained release over 3 days in vitro and in vivo.

This paper develops an electrostatically stabilized granular hydrogel with poroelasticity and strain-stiffening for biomedical applications like 3D bioprinting and wound healing.

This paper develops a hydrogel depot system to prolong the release of broadly neutralizing antibodies, showing improved pharmacokinetics and reduced immune cell-mediated release through co-formulation with anti-inflammatory agents.

This paper develops a genetically programmable protein hydrogel for sealing corneal perforations in animal models, showing effective adhesion and biocompatibility.

This study evaluates the impact of sterilization and treatment methods on oxygen-sensitive microparticles embedded in natural hydrogel matrices, finding E-beam sterilization most reliable for alginate and BSA matrices.

This paper engineers affibodies with tunable affinities for VEGF and PDGF using computational design and yeast display to improve controlled protein release from hydrogels.

This study evaluates AG-based hydrogels for expanding human salivary gland spheroids, finding AGHA gels support larger, viable, and functionally active spheroids with sustained protein expression.

This paper develops a poloxamer-based hydrogel with a self-assembling peptide for rapid in situ gelation and sustained drug delivery in an osteoarthritis mouse model.

This paper demonstrates that XCSgel, an injectable hydrogel, can localize and release immunotherapeutics to eliminate primary and abscopal murine triple-negative breast tumors with a single injection.

This paper designs a hydrogel platform with independently controllable adhesion ligand mobility and viscoelasticity, showing that dual presentation of RGD ligands on both covalent and dynamic networks maximizes endothelial cell adhesion and spreading.

This paper develops a FUS-responsive granular hydrogel system that stabilizes through crosslinking and porosity control, showing potential for minimally invasive tissue regeneration.

This study evaluates modified hyaluronic acid scaffolds infused with adipose-derived stromal cells for post-cancer breast reconstruction, showing favorable biomechanical properties and tissue integration in vitro and in vivo.

This study develops photocrosslinkable, biodegradable alginate hydrogels for controlled exosome delivery, showing that degradation rates influence exosome release kinetics.

This study develops injectable hydrogel-drug complexes that synchronize chemoimmunotherapy release to treat brain tumors in mice, achieving long-term survival and protection from rechallenge.

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

This study shows that heparin flexibility in the extracellular matrix affects VEGF mobility and bioactivity by influencing its interaction with VEGF receptor 2.

This study evaluates GelMA as a scaffold material for intestinal epithelial cells, finding it suitable for permeability, mechanical strength, and biocompatibility.

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

This study develops hyaluronic acid/eucalyptus hydrogels loaded with PLGA nanoparticles containing methotrexate as an injectable therapy for rheumatoid arthritis, showing improved stability and biocompatibility.

This study develops VEGF-coated heparin nanoparticles in MAP hydrogels to promote brain repair after stroke, showing improved tissue formation and functional recovery without free heparin.