Hematopoietic Stem Cell Transplantation

The paper identifies novel molecular markers for haemogenic endothelium and haematopoietic progenitors in mouse yolk sac using single-cell RNA sequencing and pseudotime analysis.

This study identifies a developmental program for hematopoietic stem cell (HSC) dormancy established during embryogenesis through evasion of Notch signaling, revealing a mechanism for long-term regenerative potential.

This study identifies a common precursor for monocytes and lymphoid lineages distinct from neutrophils using single-cell sequencing and lineage tracing.

This study shows that donor T cell receptor repertoires are influenced by both HLA genetics and recent viral infections, with higher HLA heterozygosity and TCR-HLA coherence linked to increased GVHD risk.

This paper introduces a serum-free co-culture system using human bone marrow stromal cells to differentiate cord blood CD34+ progenitors into B and NK cells, offering a more physiologically relevant model for hematopoiesis research.

This study compares the biological outcomes of gamma- and X-ray irradiation in mouse hematopoietic and AML transplants, finding they are functionally equivalent with proper dose calibration.

This study shows that IL-27 limits HSPC differentiation during infection and prevents stem cell exhaustion by reducing monocyte production and maintaining HSPC function.

The paper identifies distinct proteostasis programs in fetal, neonatal, and adult hematopoietic stem cells, showing how proteostasis changes during development and impacts stem cell function.

This study develops a microgel-based bone marrow model to study mesenchymal stem cell (MSC) paracrine signaling's role in hematopoietic stem cell (HSC) retention and expansion.

The paper develops a bioengineered bone marrow model that supports stem cells and mimics disease metabolism and chemotherapy effects, showing enhanced taurine metabolism and chemotherapy response.

This study identifies ERAD activity as a predictive and heritable marker of hematopoietic stem cell function by linking cytokine signaling to proteostasis remodeling.

This study shows that closely matched myeloid progenitor cells can protect skin and trachea grafts without lethal preconditioning or HSC transplantation.

This study examines how murine limb ischaemia affects bone marrow structure and function, revealing both local and systemic changes in haematopoiesis and myeloid cell function.

This paper shows that CD201 is a more reliable marker than SCA1 for identifying long-term reconstituting hematopoietic stem cells in mice after septic challenge.

The paper shows that mitochondrial content influences lineage commitment in megakaryocyte-erythroid progenitors, with mitochondria-rich cells favoring erythroid differentiation and mitochondria-poor cells favoring megakaryocyte differentiation.

This study shows that erythroid precursors in the bone marrow increase local oxygen levels after injury, promoting tissue repair by enhancing angiogenesis and osteogenesis.

The paper investigates the roles of Atf3, Zfp711, and Bcl6b in early hemato-endothelial lineage specification using scRNA-seq and KO mESCs, finding distinct effects on mesodermal and hematopoietic lineages.

This study shows that syndecan-2 in mesenchymal stromal cells, but not endothelial cells, supports HSC self-renewal and cytokine responses by modulating growth factor signaling.

The paper identifies a mesodermal progenitor in mouse gastrula and human iPSC cultures that gives rise to pro-definitive angio-hematopoietic lineage cells, including yolk sac endothelium, blood islands, and macrophages.

The paper creates a spatial atlas of human gastrointestinal GVHD, identifying immune and epithelial changes that contribute to disease pathophysiology.

The paper develops a single-cell transcriptomic map of cynomolgus macaque hematopoietic stem cells and progenitors, revealing molecular differences from humans and a direct differentiation pathway to megakaryocyte lineages.

This study shows that inhibiting farnesyltransferase reduces the ex vivo expansion of human and mouse hematopoietic stem cells.

The paper shows mitofusin agonists enhance long-term repopulating activity of human cord blood HSCs in ex vivo culture without changing total nucleated cells or phenotypic HSCs.

This study shows that CNOT3 deletion in HSCs causes anemia, reduced bone marrow cellularity, and impaired hematopoietic reconstitution.

This study shows that linker histone H1.0 regulates HSPC fate bias toward lymphoid or myeloid differentiation, with H1.0 levels decreasing in response to IFN signaling.

This study identifies desaminotyrosine (DAT) as a microbial metabolite that protects against graft-versus-host disease by promoting intestinal regeneration and modulating immune responses.

This study identifies GABA as a regulator of HSPCs produced by B cells and endothelial cells in the bone marrow, showing lower GABA levels reduce proliferation and increase B cell differentiation.

This study identifies PERK activation in bone marrow endothelium as a regulator of DLL4-NOTCH3 signaling, which enhances lymphoid regeneration after transplantation.

This paper identifies Cyp7b1-inhibiting azoles as enhancers of HSPC mobilization, particularly effective in SCD patients.

This study optimizes the dose and timing of MSC-derived culture-conditioned media (CCM) to enhance its immunomodulatory effects on CD3+ T-cells in acute graft-versus-host disease.