Gastrointestinal motility and disorders

The paper develops a computational model to simulate inflammation-driven colon hypertrophy and motility changes in Gulf War Illness using PB-exposed mouse data.

This paper introduces a non-invasive method to measure oral-cecal transit time in mice by tracking microbial oxidation of 13C-mannitol to 13CO2 using spectroscopy and calorimetry.

This study investigates how loss of the enteric nervous system in zebrafish affects intestinal cell composition and identifies similar changes in human HSCR tissues.

This study profiles the gastrointestinal tract over three months post-stroke in an experimental model, showing structural and microbial changes that persist chronically.

This study introduces an immune-competent colon assembloid model to investigate how neuroinflammation affects colonic motility, finding impaired neuronal regeneration and smooth muscle remodeling as key mechanisms.

This study develops a novel benzodiazepine, Li633, that targets peripheral GABAA receptors to reduce visceral pain in IBS and FD models.

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

The paper identifies an estrogen-responsive paracrine pathway in the gut that increases sensitivity in females by enhancing communication between enteroendocrine cells and sensory nerves.

The paper develops an optogenetics-integrated gut organ culture system to study enteric neuron dynamics and their impact on gut homeostasis, revealing distinct neuronal roles in immune and barrier functions.

This study identifies the PPARD/PDK4/ANGPTL4 pathway as a mechanism by which obesity induces phenotypic switching of gastric smooth muscle cells, leading to dysmotility.

The paper shows that different luminal nutrients activate distinct calcium responses in submucosal and myenteric neurons of the mouse small intestine.

This paper introduces a compartmental model of the gut-brain axis to simulate gastric function regulation, showing inhibitory and excitatory effects of sympathetic and parasympathetic pathways on digestion.

This study identifies Gpr37 as a gene expressed in enteric glia cells of the myenteric plexus and shows its role in LPS-induced reactive gliosis and GI dysmotility.

This study shows that enteric glia regulate Paneth cell secretion and microbial ecology but have minimal effects on overall intestinal epithelial transcription.

The paper identifies Cdh6 as a marker for a novel class of sensory neurons in the mouse colon that regulate colonic motility through specific electrophysiological properties and functional responses.

This study shows enteroendocrine cells are essential for maintaining intestinal barrier integrity and that their secreted hormones PYY and octreotide can restore barrier function in inflammatory conditions.

The paper investigates how peristaltic wave origins in chicken embryos transition from random to organized positions through suppressive actions and lateral inhibition.

This systematic review examines attentional deficits and brain-gut axis interactions in IBS patients, identifying attentional biases and altered brain activation patterns.

This study identifies glutamatergic neurons as key regulators of intestinal motility by showing their synaptic connections and functional roles in gut transit.

This study identifies distinct roles for crypt and villus enterochromaffin cells in sensing gut irritants and oxidative stress through different TRP channels and signaling mechanisms.

This study investigates mechanisms of serotonin release from human enterochromaffin cells using organoids and functional assays, identifying key receptors and signaling pathways involved.

This paper demonstrates GI MRI in conscious rats, showing faster gastric emptying and stronger peristalsis compared to anesthetized rats.

This study shows T cells regulate intestinal motility and enteric neuronal responses to microbiota, with distinct roles in ileum and colon.

This study investigates how colitis and the adaptive immune system regulate intestinal motility in the ileum and colon using a mouse model.

This study investigates the intestinal barrier function in naked mole-rats, finding reduced gut permeability and diminished secretory responses compared to mice.

This study characterizes dopaminergic neurons in the gut using a DAT-cre reporter mouse line, revealing distinct subtypes with dual-transmitter content.

This study shows that peripheral serotonergic neurons affect gut motility and anxiety-like behavior, suggesting potential therapeutic targets.

The paper characterizes VGLUT2-positive enteric neurons in mice, revealing their unique morphology, gene expression, and functional activation via colorectal stretch.

This study investigates the role of Cntnap2 in GI motility using Cntnap2 mutant mice, finding altered colonic motility without affecting ENS organization.