Cellular Mechanics and Interactions

This study shows that motor-driven cargo transport can sort actin filaments into polarity domains separated by cargo clusters, with effects influenced by cargo number, motor density, and filament length.

This paper introduces genetically encoded mechano-sensors using coiled coils to measure mechanical forces in vivo with diverse readouts and compact design.

The paper identifies a weak, integrin-independent adhesion-clutch mechanism involving shootin1 and L1 that enables rapid cell migration and glioblastoma motility by transmitting weak traction forces.

The paper uses agent-based simulations calibrated with microscopy data to predict and validate how microscopic actin dynamics affect cortical flow speed in C. elegans zygotes.

This study shows that ECM stiffness influences site-specific lung development in organoids by directing cell differentiation and pathway activation.

The paper screens 2,418 kinase inhibitors across five human cell types to identify cell-type specific contractility responses and challenges assumptions about pathway conservation.

The paper identifies two conserved mechanisms controlling cytoplasmic macromolecular diffusion in C. elegans tissues, involving ribosome concentration and the giant KASH protein ANC-1.

This study uses an agent-based model to show that catch-slip bonds enhance the mechanical properties of polymer networks and aid myosin motors in generating contractile forces.

The paper introduces the STIPS algorithm to track merging and splitting events in dynamic biopolymer networks, revealing distinct rhythmic dynamics in actin microridges.

This study investigates how actin networks coexist under resource competition by using a reconstituted system, showing that protein turnover enables coexistence but intense competition favors stronger networks.

The paper studies oscillations in epithelial cell trains, showing that spontaneous oscillations depend on cell train size and exhibit resonance when subjected to external deformations.

The paper shows that α-catenin phosphorylation during mitosis prevents apical rounding and epithelial barrier leak by strengthening cell-cell interactions.

This paper investigates how stem cells adapt to mechanical cues by remodeling their cytoskeleton, showing that microtubule stabilization and substrate compliance significantly influence cell mechanics and morphology.

This paper investigates how microtubule stabilization and mechanical compression affect cytoskeletal remodeling in stem cells, showing changes in cell mechanics and structure.

The paper models cell alignment with collagen fibrils using a hybrid model showing mechanosensitive focal adhesions drive ECM-dependent cell elongation.

The paper shows that increased cell contractility in pre-tumoral tissues drives tumour aggressiveness through dysplasia and junction weakening.

This study shows that substrate curvature affects macrophage cytoskeletal dynamics and immunophenotype, offering a localized strategy to modulate macrophage behavior.

The paper uses cSTAR to analyze endothelial cell transcriptomic states under different flow conditions, identifies CDK2 as a key regulator of artery remodeling.

The paper shows that mechanical compression increases PI3K signaling in breast and pancreatic cancer cells, enhancing resistance to PI3K inhibitors and affecting autophagy.

This paper introduces a time-shared optical tweezer microrheology method to measure age-dependent viscoelastic properties of biological materials, demonstrating its application in biomolecular condensates, zebrafish cells, and C. elegans.

This study shows GBM cells use Plexin-B2 to regulate membrane tension and mechano-electrical coupling for migration through confined spaces.

This study shows that CD44/Integrin β1 association enables faster cell motility on HA substrates by forming smaller, weaker focal adhesions.

The paper investigates the role of elastic bending tensions in embryonic body folding, showing that ECM integrity and differential tension between tissue layers drive the process.

This study uses agent-based simulations to show that mechanical feedback from cell division and proliferation influences cell dynamics in growing tissues, with distinct diffusion behaviors depending on feedback strength and growth rate.

This study shows that histone acetylation via HDACi alters nuclear morphology in hMSCs depending on substrate rigidity, with effects on soft substrates being reversible by HDACi treatment.

The paper shows that intraluminal pressure rapidly strengthens endothelial barriers through actin reorganization and paracellular gap closure, lasting up to 30 minutes.

This study investigates how hydrostatic pressure modulates endothelial cell responses to flow, showing pressure alters shear-induced signaling and transcriptional changes in human and mouse ECs.

This paper introduces a microfluidic rheometer to measure tumor spheroid mechanics and invasiveness in a physiologically relevant setting, finding that tumor stiffness and viscoelastic properties correlate with invasiveness.

This paper develops a platform to study how ECM nanotopography affects cell ultrastructure using cryo-ET and electrospun fibers.