Leeya Engel

This paper introduces a wafer-scale fabrication method for all-gold EM grids that enable on-grid actin organization through anisotropic foil geometry without chemical micropatterning.

This study uses cryo-ET to show that MYH7 P710R mutations disrupt thick filament organization in HCM cardiomyocytes, leading to sarcomeric disarray and ribosome infiltration.

The paper uses cryogenic electron tomography to redefine herpesvirus capsid assembly intermediates inside the cell nucleus by deriving atomic models and revealing structural heterogeneity in capsid components.

This paper develops a platform to study how ECM nanotopography affects cell ultrastructure using cryo-ET and electrospun fibers.

This study uses cryo-ET to analyze the structure of thin filaments in human iPSC-derived cardiomyocytes and how they change with disease-related perturbations.