Lipid Membrane Structure and Behavior

This study uses all-atom simulations to reveal that guanine in RNA has the strongest interaction with membranes, while base pairing reduces membrane binding.

The paper identifies lipid binding sites on AqpZ using native mass spectrometry and molecular dynamics, revealing selectivity for cardiolipins at specific sites.

This study demonstrates that cationic liposomes can fuse with membranes to deliver cargo efficiently but temporarily alter membrane properties.

This study uses molecular dynamics simulations to investigate how lipid composition and properties influence membrane stability and pore formation in different biological membranes.

This study investigates how Neospora caninum alters host cell membrane order using LAURDAN fluorescence and hyperspectral imaging, revealing cholesterol redistribution and its impact on membrane fluidity.

The paper uses spectrally resolved single molecule orientation imaging to show a direct link between polarity and order in lipid bilayers.

This paper develops a biophysical model of the glycocalyx's role in generating and sensing membrane curvature, showing how glycocalyx properties influence membrane shape and curvature sensing.

This paper introduces MemGraft, a covalent fluorescent labeling method for plasma membranes that enables long-term imaging, barcoding, and manipulation of cells without probe exchange.

This study presents the highest resolution cryo-EM structure of a BAR protein and shows endophilin B1 permeabilizes liposomes containing cardiolipin, proposing a new model for Bax-mediated cell death.

This study investigates how septins organize membranes through self-assembly and identifies key domains involved in membrane remodeling and curvature sensing in yeast.

This study uses MD simulations to analyze the self-assembly of mycolic acids in water, revealing structural properties and conformational changes in monolayers and mixtures, with quantitative agreement with experimental results.

The paper uses neutron scattering techniques to study how glycolipids affect membrane mechanics and dynamics in polydisperse oligolamellar vesicles.

This study uses molecular dynamics simulations to examine how membrane composition affects biophysical properties of the inner membrane in four Gram-negative bacteria, highlighting cardiolipin's role.

This study models vesicle translocation through membrane-covered pores, showing that adhesion energy and membrane deformation influence translocation efficiency and barrier height.

This study uses computational methods to analyze how different cell-penetrating peptides interact with and disrupt cell membranes, identifying mechanisms based on lipid composition and peptide type.

This study uses simulations to show cholesterol stabilizes EphA2 dimerization and TM-JM interactions with PIP2, highlighting membrane composition's role in EphA2 signaling and cancer progression.

This study investigates how halogenated cholesterol affects lipid phase behavior in ternary membranes using cryo-EM and fluorescence microscopy.

This study compares lipid-based probes for plasma membrane labeling in live, fixed, and permeabilized cells, identifying a superior probe based on its lipid structure.

This study investigates how membrane phase, temperature, and lipid composition affect proton transfer and diffusion on biological membranes.

The paper develops modular fluorescent cholesterol analogs to study subcellular cholesterol trafficking, showing that head group modifications affect internalization efficiency and subcellular distribution.

This study uses molecular dynamics simulations to show that RNA order determines its interaction with zwitterionic lipid bilayers, explaining experimental observations about RNA affinity for gel-phase membranes.

The paper uses simulations to show that LHCII in plant thylakoid membranes redistributes non-bilayer lipids, resisting polymorphism and controlling curvature for non-photochemical quenching.

This study shows that the {beta}2AR surface facilitates drug membrane permeation, with over 50% of flip-flop events using this pathway, suggesting its importance for drug design.

This study uses molecular dynamics simulations to investigate how the HIV-1 fusion peptide inserts and anchors into a T-cell membrane mimic, identifying a critical motif for fusion.

The paper uses continuum elastic theory to show lipid demixing reduces energy barriers for high curvature vesicle budding, but requires phase separation for significant compositional deviations.

This study examines how Ca2+ affects the structure and dynamics of PIP3 in model membranes with PC and PS using NMR and MD simulations.

This study uses an in vitro model to show how membrane phase separation and bacterial division protein dynamics are interdependent during cell division.

This study examines cryo-EM structures of membrane proteins in nanodiscs, revealing spatial preferences and direct interactions with MSPs that stabilize proteins.

This paper introduces a platform for high-throughput extraction of membrane proteins into native nanodiscs while preserving their local membrane context and provides a database for optimized extraction conditions.

The paper investigates how lipid transporters, cargo, and membrane properties coordinate during non-vesicular lipid transport in yeast.