Cannabis and Cannabinoid Research

This study uses PET and MRI to assess CB2R levels and metabolic changes in a mouse model of cerebral ischemia, finding increased CB2R and reduced glucose metabolism in the ischemic striatum.

The paper identifies synucleins as essential for vesicular exocytosis of endocannabinoids, linking their role in Parkinson's Disease to synaptic plasticity.

This study examines chronic THC vapor inhalation's effects on pain and vlPAG neuronal function in rats, finding sex-specific rescue of thermal hyperalgesia and cell type-specific modifications in neuronal properties.

The paper examines how genetic and epigenetic factors at AKT1 rs1130233 modulate THC-induced brain activation during fear processing in healthy males.

This study shows that NIDA-produced Cannabis sativa lacks genetic diversity compared to state market varieties, limiting the generalizability of research findings.

The paper identifies a differential role of CB1-expressing interneurons in controlling pyramidal neuron activity in primary and secondary visual cortical areas through distinct endocannabinoid mechanisms.

The paper uses explainable machine learning to identify gender-specific risk factors for cannabis use disorder, finding stronger environmental influences in women and individual factors in men.

The paper quantifies heritability of THC responses in BXD mice strains and identifies candidate genes associated with variation in initial sensitivity to THC effects.

The paper assesses the genetic and chemical consistency of CBD hemp accessions, finding significant variability and reliability issues in commercial varieties.

The paper uses deep learning to analyze cerebellar morphology across species, finding sex and cannabinoid signaling influence folding patterns.

The paper predicts essential binding domains of AEA in the CB1 receptor using molecular dynamics simulations, identifying the hydrophobic channel and H2/H3 region as critical for AEA binding.

This study shows that repeated low-dose THC impairs memory in mice through serotonergic signaling via 5-HT2ARs, as evidenced by increased CB1R/5-HT2AR heterodimers and reduced LTP.

This study shows that cnr2 is critical for ribbon synapse maturation and function in hair cells and photoreceptors, affecting synaptic structure and behavior in zebrafish larvae.

This study investigates the role of the endocannabinoid system in reprogramming Muller glia into progenitor cells in the retina, showing that eCB signaling promotes this process while suppressing NFkB activity in mouse Muller glia.

This study shows that endocannabinoids and dopamine interact to modulate long-term plasticity in the entopeduncular nucleus, influencing the balance of direct and indirect output dominance.

This study shows that inhibiting diacylglycerol lipase reduces alcohol consumption in preclinical models and prevents ethanol-induced suppression of GABAergic transmission without causing anxiety or depression.

This paper develops a mouse model to study cocaine-seeking behavior and incubation of craving, finding that cannabidiol reduces cocaine self-administration but not craving incubation, depending on administration timing.

This study examines how CBD and THC affect striato-cortical connectivity in the human brain using fMRI, finding THC disrupts connectivity while CBD mitigates some effects and has mixed impacts when used alone.

This study shows that hepatic CB1R regulates soluble leptin receptor (sOb-R) levels through CHOP, contributing to leptin resistance in diet-induced obesity.

This study examines the effects of adolescent THC exposure on behavior, brain structure, and gene expression in rats, finding altered psychological and brain development but no clear support for the Gateway Hypothesis.

This study shows that CB1 receptor deletion affects cerebellar learning indirectly through altered behavioral state rather than direct synaptic plasticity effects.

This study identifies sex-specific developmental differences in endocannabinoid-mediated LTD in rat prefrontal cortex, showing distinct receptor usage and timing of eCB-LTD emergence between males and females.

The paper investigates the relationship between central CB1-receptor availability and peripheral endocannabinoids in first-episode psychosis patients and healthy controls, finding dysregulated cross-talk between these systems.

This study shows that Reelin deficiency exacerbates long-term behavioral issues in mice exposed to THC during adolescence, including impaired social behavior and increased novelty seeking.

This study investigates how the cannabinoid agonist CP-55,940 affects sign-tracking and goal-tracking behaviors in rats, finding that it decreases sign-tracking and increases goal-tracking in a dose-dependent manner.

This study shows that THC exposure via lactation during early postnatal life leads to lasting behavioral and synaptic deficits in adult rats.

This study examines how early-life stress affects cerebellar endocannabinoid levels and behavior, revealing sex-specific differences and potential contributions to brain sexual differentiation.

This study examines whether cannabis use extent predicts psychotic-like and euphoric intoxication experiences in First Episode Psychosis patients and controls, finding a significant interaction between caseness and use frequency.

The paper generates and characterizes a mutant mouse lacking mitochondrial-associated CB1 receptors to study their role in brain function and drug effects.