Angiogenesis and VEGF in Cancer

This study identifies Vegfr3 as a regulator of brain vessel branching and filopodia formation in a Tbx1 mutant mouse model of 22q11.2 deletion syndrome.

This study identifies Rab35's role in regulating actin dynamics to establish apicobasal polarity during sprouting angiogenesis.

This study investigates the role of SRF in mural cells, showing its importance in pericyte migration, vessel patterning, and blood flow during development and disease.

The paper analyzes RNA-seq data to identify key biological processes and signaling pathways in TCF21-overexpressed tumor pericytes, highlighting MAPK and complement/coagulation pathways and several interacting molecules.

This study identifies N-VEGF as an autoregulatory component of VEGF-A that promotes hypoxia-induced gene expression and cell survival.

The paper identifies naturally occurring receptor combinations in endothelial cells using single-cell data and introduces a software tool to analyze them, showing evolutionary conservation and relevance to angiogenesis.

This study shows that inhibiting prolyl hydroxylases with DMOG impairs angiogenic competence of human vascular endothelial cells through metabolic reprogramming.

This study shows that Vegfa isoforms differentially regulate endothelial cell proliferation via PI3K signaling, independent of MAPK (ERK) activation in zebrafish.

This study identifies Svep1 as a factor that stabilizes vascular anastomosis in zebrafish embryos under reduced flow conditions.

This study shows endostatin inhibits epimorphic regeneration in mice by blocking bone marrow-derived CD31+ endothelial precursor recruitment, unlike its effect on wound repair.

This study shows that inhibiting STAT3 reduces VEGF-induced vascular permeability in zebrafish, mice, and human endothelium, suggesting a therapeutic target for diseases involving vascular leakage.

This study identifies significant associations between VEGF SNVs and head and neck cancer risk and tumor characteristics in a South Asian population.

This study shows ATP6AP2 is essential for endothelial cell polarity and extracellular matrix production during both normal and disease-related blood vessel growth.

This study investigates the role of Rasip1 in endothelial cell behaviors during angiogenesis and anastomosis in zebrafish, revealing its critical function in cell pairing and junction stability.

The paper evaluates how vascular branching morphology affects blood flow and oxygen transport during angiogenesis using computational simulations and mouse models.

This study shows that VEGFC induces cell-cycle arrest in endothelial cells, promoting sprouting and differentiation in venous and lymphatic vessels.

This study uses a zebrafish Erk biosensor to live-image dynamic Erk-signalling events during regenerative angiogenesis, revealing sequential Ca2+- and Vegfr-dependent mechanisms.

This study shows that Slp2a is essential for vascular lumen formation by regulating Weibel-Palade body exocytosis and angiopoietin-2 release during angiogenesis.

This study identifies Nucleolin as a factor reactivated in gliomas that promotes angiogenesis and endothelial metabolism by regulating glycolysis through p53-TIGAR-HK2.

This study identifies TUBB8 as the molecular target of benzimidazoles, revealing their mechanism of vascular disruption and potential clinical applications.

This study shows that oligodendroglial HIF regulates CNS angiogenesis via VEGF-dependent signaling, independent of Wnt, and reveals a glial cell type-specific HIF-Wnt axis.

This study identifies nxhl as a novel upstream regulator of VE-PTP in angiogenesis by interacting with NCL, revealing a new signaling pathway with therapeutic potential for angiogenesis-dependent diseases.

This study shows that ETS1 and ETS2 redundantly regulate M-phase progression and cell survival in post-natal angiogenesis by controlling G2/M regulators and anti-apoptotic genes.

The paper shows that Vegfa from alveolar type 1 cells specifies a distinct endothelial population in the mouse lung, marked by Car4 and involved in alveologenesis.

The paper shows that pericytes enhance angiogenesis under high TNF doses, with a mathematical model explaining the switch from pro- to anti-angiogenic effects of TNF.

This study shows that Caspase-8 promotes angiogenesis in endothelial cells through a cell death-independent mechanism involving p38 MAPK activation and VE-cadherin destabilization.

The paper constructs a systems biology model to explore how extracellular pro- and anti-angiogenic factors regulate tumor angiogenesis, revealing a counterintuitive role for PF4 in enhancing pro-angiogenic signaling.

The paper identifies a positive-feedback mechanism involving Tm4sf18 that accelerates and stabilizes endothelial cell decision-making during angiogenesis.

The paper proposes and analyzes a VEGF reaction-diffusion mechanism for tip cell selection in angiogenesis, showing variable tip cell densities based on local VEGF production rates.

The paper shows Etv6 regulates vegfa expression in Xenopus blood stem cells by both repressing foxo3 and activating klf4, with Klf4 recruiting Etv6 to the vegfa promoter.