Anesthesia and Sedative Agents

Aperiodic exponent ceases to track changes in propofol dose at deep surgery-level hypnotic depths

The paper examines if the aperiodic exponent tracks propofol dose changes at deep hypnotic depths, finding it does not.

Early reactivation of medial temporal lobe neurons during emergence from propofol anesthesia in neurosurgical patients

This study records single neuron activity in humans during emergence from propofol anesthesia, showing increased firing rates and shifts in brain activity patterns in medial temporal regions before motor response to verbal command.

Multimodal profiling reveals the centromedian nucleus of thalamus as a dynamic hub orchestrating staged consciousness recovery

This paper develops a multiscale framework to decode consciousness recovery from anesthesia into three stages and identifies the centromedian nucleus of thalamus as a dynamic hub orchestrating this process.

A Novel Conditional Adra2a-Knockout Mouse Line Reveals Cell-specific Contributions to Specific Dimensions of Sedation

This study creates a conditional Adra2a knockout mouse line and shows cell-specific contributions of the 2A adrenergic receptor to sedation, hypnosis, and hypothermia.

Neuronal Dynamics During Isoflurane Induction in Caenorhabditis elegans

This study uses C. elegans to show that isoflurane induction causes gradual neuronal disconnection and disorganization, reversing the dynamics seen during emergence from anesthesia.

Pharmacological recruitment of a VTA glutamatergic arousal circuit by the natural product BN3 drives broad-spectrum emergence from general anesthesia

The paper identifies BN3 as a broad-spectrum agent that accelerates emergence from general anesthesia by targeting a VTA glutamatergic arousal circuit.

Dexmedetomidine produces more sleep-like brain activity compared to propofol

This study compares brain activity during dexmedetomidine and propofol anesthesia to natural sleep using iEEG, finding dexmedetomidine more similar to sleep in certain metrics.

Locus Coeruleus to Medial Prefrontal Cortex Noradrenergic Neural Circuit Modulates States of Consciousness during Sevoflurane Anesthesia in Mice

This study investigates how sevoflurane anesthesia affects consciousness by examining the role of locus coeruleus to medial prefrontal cortex noradrenergic circuits in mice.

Light propofol anaesthesia for non-invasive auditory EEG recording in unrestrained non-human primates.

This study uses propofol sedation to enable non-invasive auditory EEG recording in unrestrained non-human primates, showing it allows high-quality data collection with minimal stress.

Effects of ketamine and propofol on muscarinic plateau potentials in rat neocortical pyramidal cells

This study investigates how ketamine and propofol affect muscarinic plateau potentials in rat neocortical pyramidal cells under simulated awake-like conditions.

Restoring the loss of consciousness under sevoflurane anesthesia in states of anxiety and depression by potently activating serotonergic pathways in brain

This study identifies a serotonergic pathway between the central amygdala and medial prefrontal cortex that accelerates sevoflurane anesthesia recovery, particularly in individuals with anxiety and depression.

Mapping general anesthesia states based on electro-encephalogram transition phases

The paper develops an algorithm to predict general anesthesia overdose by analyzing EEG transition phases in mice, identifying key patterns that anticipate overdose several minutes in advance.

Responsiveness variability during anaesthesia relates to inherent differences in brain structure and function of the fronto-parietal networks

The paper shows that variability in responsiveness during propofol anaesthesia is linked to differences in brain structure and function of fronto-parietal networks, which can be predicted before sedation.

A high-cholesterol diet leads to faster induction of general anesthesia in two model animals: D. magna and C. elegans

The paper shows that a high-cholesterol diet speeds up anesthetic induction in D. magna and C. elegans, supporting a lipid-based mechanism for general anesthesia.

The effect of combined dexmedetomidine and isoflurane anaesthesia on visually evoked responses in rats -- an electrophysiological study

This study examines the effect of combined dexmedetomidine and isoflurane anaesthesia on visual evoked responses in rats, finding reduced but not fully suppressed responses in the visual cortex.

The 5-hydroxytryptaminergic Neurons Locating in the Dorsal Raphe Nucleus and Different Receptors of 5-HT Were Implicated in Mediating the Arousal from Sevoflurane Anesthesia

The study investigates the role of 5-HT neurons and their receptors in mediating delayed awakening from sevoflurane anesthesia in mice.

Complexity of brain dynamics as a correlate of consciousness in anaesthetized monkeys

This study measures brain activity complexity in anaesthetized monkeys to correlate with consciousness levels, finding changes in complexity with different anaesthetics.

EEG microstate dynamics indicate a U-shaped path to propofol-induced loss of consciousness

This study examines EEG microstate dynamics during propofol-induced loss of consciousness, finding a U-shaped change in sequence complexity linked to altered states of consciousness.

Propofol Anesthesia Concentration Rather Than Abrupt Behavioral Unresponsiveness Linearly Degrades Responses in the Rat Primary Auditory Cortex

This study shows that propofol anesthesia concentration, not abrupt behavioral changes, linearly degrades auditory cortex responses in rats.

A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography.

This study compares the effects of GABA-ergic propofol and non-GABA-ergic dexmedetomidine on visual and motor cortical oscillations using MEG, finding distinct impacts on gamma-band responses and post-movement beta rebound.

Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness

This study assesses the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness using statistical models and physiological data from nine volunteers.

Detecting the state of drowsiness induced by propofol by spatial filter and machine learning algorithm on EEG recording

This paper uses a CNN on EEG power spectra to predict drowsiness during propofol anesthesia, achieving 96.47% test accuracy.

Electrocorticography based monitoring of anaesthetic depth in mice

This paper develops an electrocorticography-based system to monitor anaesthetic depth in mice using gradient boosting regression, achieving real-time tracking with ten-second latency.

Depth of sedation with dexmedetomidine modulates cortical excitability non-linearly

This study examines how dexmedetomidine sedation depth affects cortical excitability, finding non-linear changes and region-specific effects.

Recovery of Consciousness and Cognition after General Anesthesia in Humans

This study investigates recovery of consciousness and cognition after general anesthesia in humans, finding that executive function recovers before other cognitive domains and frontal cortical activity recovers faster than posterior.

The effect of hydrophobic gases on the nervous system of Daphnia magna

This study investigates the effects of xenon, nitrous oxide, and krypton on the nervous system of Daphnia magna under water, finding that these gases can suppress harmful sensations.

Dexmedetomidine - commonly used in functional imaging studies - increases susceptibility to seizures in rats but not in wild type mice

This study shows that dexmedetomidine increases seizure susceptibility in rats but not in mice, affecting hemodynamic and neurophysiological responses to stimulation.

Electroencephalogram Monitoring of Depth of Anesthesia during Office-Based Anesthesia

This study develops an automated EEG-based method to monitor sedation levels during office-based anesthesia using spectral features and achieves an AUC of 0.85.

Alfaxalone activates Human Pregnane-X Receptors with greater efficacy than Allopregnanolone: an in-vitro study with implications for neuroprotection during anesthesia.

This study compares the efficacy of alfaxalone and allopregnanolone in activating human pregnane X receptors using an in vitro assay with HEK293 cells.

Neural signatures of α2 adrenergic agonist-induced unconsciousness and awakening by antagonist

The paper examines neural dynamics during anesthetic-induced unconsciousness and awakening in non-human primates, finding that an antagonist can restore consciousness without an intermediate state.