Muscle Physiology and Disorders

This study identifies exercise-related microRNAs in C. elegans that regulate calcium homeostasis and mitochondrial dynamics, showing conserved pathways but divergent microRNAs across species.

This study identifies an aberrant FAP subpopulation in VML that drives fibrosis and presents potential targets for scarless muscle regeneration.

This study examines how frailty syndrome affects skeletal muscle histology in mice and shows that exercise can prevent these negative changes.

This paper introduces SMPFO, a method combining fluorescence assays and proteome profiling to study skeletal muscle, revealing reduced myofiber subtype divergence in nemaline myopathy.

This study shows that ERK signaling duration regulates muscle stem cell plasticity in axolotl tail regeneration, with distinct phases promoting fibroblast and chondrocyte fates.

This study shows that unacylated ghrelin prevents muscle and mitochondrial dysfunction in cancer cachexia by improving muscle mass, mitochondrial function, and reducing proteolysis.

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

This study shows that Dp71 dystrophin is essential for macrophage development and function, as its absence disrupts migration, phagocytosis, and inflammasome activity in mouse macrophages.

This study identifies DUSP22 as a novel target for preventing skeletal muscle wasting by repressing the JNK-FOXO3a pathway independently of Akt.

This study shows GL261 glioblastoma tumors in young mice reduce skeletal muscle growth, mass, and protein synthesis while altering catabolism signaling.

This study identifies myostimulin, a protein derived from C1ORF54, which enhances muscle function and recovery in mice, suggesting its potential as a therapeutic for musculoskeletal diseases.

The paper identifies polysialylated NCAM as a marker distinguishing differentiated from proliferating myoblasts before fusion.

This study shows that muscle fiber Myc is not required for muscle growth but its overexpression disrupts muscle structure and function.

The paper investigates how resistance exercise and mechanical overload upregulate vimentin in skeletal muscle, linking it to hypertrophy and regeneration.

This study shows that liver-derived Yap1 activation during organ repair induces systemic catabolism and muscle loss, similar to cancer cachexia.

This study examines gene expression changes in C2C12 myotubes under hyperthermia with and without insulin treatment, finding upregulated metabolic and stress-related genes and insulin's moderating effect on these changes.

This study identifies the short isoform of SYNPO2 as a pro-myogenic factor that enhances myotube formation and upregulates late myogenic differentiation markers.

This study identifies bazedoxifene as a potential treatment for LGMD R2 through high-throughput screening of drugs targeting dysferlin aggregation.

This study investigates BMD mice with specific exon deletions, showing site-specific muscle degeneration, type IIa fiber reduction, and capillary changes linked to nNOS reduction.

This study shows that exercise improves IGF-1 signaling and muscle function in aged mice, enhancing physical performance and mitigating age-related muscle decline.

This study investigates whether muscle-specific Keap1 deletion prevents inactivity-induced muscle atrophy in mice, finding it enhances force production but does not prevent atrophy or weakness after hindlimb unloading.

The paper investigates the role of EZH2 in Duchenne muscular dystrophy and shows that inhibiting EZH2 improves muscle phenotype in Dmd mutant mice when combined with glucocorticoids.

This study identifies Galectin-3 as a driver of inflammation in LAMA2-CMD and shows that inhibiting it reduces inflammation and fibrosis in a mouse model.

This study uses human iPSC-derived myocytes to model statin-induced myopathy, showing statins impair proteostasis via the mevalonate pathway and identify FOXO1 as a target for prevention.

The paper uses single-nuclei RNA-sequencing to identify NMJ-specific transcripts and shows that Etv4 and Pdzrn4 contribute to NMJ stability through gene regulation and protein interactions.

This study shows that 3D mechanical confinement regulates muscle stem cell fate by maintaining stemness and inhibiting differentiation through epigenetic and nuclear changes.

This study examines changes in motor unit conduction velocity after unilateral lower limb suspension and active recovery, finding that ion channel gene expression, particularly K+ transporters, correlates with these changes.